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10.1309/AJCPA1WN7ARPCMKQ

http://scihub22266oqcxt.onion/10.1309/AJCPA1WN7ARPCMKQ
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C4624292!4624292 !23765537
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suck abstract from ncbi


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pmid23765537
      Am+J+Clin+Pathol 2013 ; 140 (1 ): 82-90
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  • Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children s Oncology Group #MMPMID23765537
  • Rudzinski ER ; Teot LA ; Anderson JR ; Moore J ; Bridge JA ; Barr FG ; Gastier-Foster JM ; Skapek SX ; Hawkins DS ; Parham DM
  • Am J Clin Pathol 2013[Jul]; 140 (1 ): 82-90 PMID23765537 show ga
  • OBJECTIVES: To examine whether the frequency of fusion-negative alveolar rhabdomyosarcoma (ARMSn) increased coincident with changes in the definition of alveolar histology. METHODS: We re-reviewed alveolar rhabdomyosarcoma (ARMS) in the Children's Oncology Group study D9803, comparing histopathology with fusion status. RESULTS: Our review of 255 original ARMS cases (compared with a control group of 38 embryonal rhabdomyosarcomas [ERMS] cases) revealed that many had an ARMS-like densely cellular pattern with cytologic features and myogenin expression more typical of ERMS. Following re-review, 84 (33%) cases of original ARMS were rediagnosed as ERMS. All reclassified ERMS, including dense ERMS, were fusion negative, whereas 82% of confirmed ARMS cases were fusion positive. Total ARMS diagnoses returned to historic rates of 25% to 30% of all rhabdomyosarcomas, and ARMSn decreased from 37% to 18% of ARMS cases. The outcome of reclassified ERMS was similar to confirmed ERMS. CONCLUSIONS: To address the role of fusion status in risk stratification, pathologists should include both a histologic diagnosis and an evaluation of fusion status for all new ARMS diagnoses.
  • |Child [MESH]
  • |Diagnosis, Differential [MESH]
  • |Disease-Free Survival [MESH]
  • |Forkhead Box Protein O1 [MESH]
  • |Forkhead Transcription Factors/genetics [MESH]
  • |Humans [MESH]
  • |In Situ Hybridization, Fluorescence [MESH]
  • |Myogenin/*metabolism [MESH]
  • |Ohio [MESH]
  • |Oncogene Proteins, Fusion/*genetics [MESH]
  • |PAX3 Transcription Factor [MESH]
  • |PAX7 Transcription Factor/genetics [MESH]
  • |Paired Box Transcription Factors/*genetics [MESH]
  • |Paraffin Embedding [MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction [MESH]
  • |Rhabdomyosarcoma, Alveolar/*classification/metabolism/pathology [MESH]
  • |Rhabdomyosarcoma, Embryonal/*classification/metabolism/pathology [MESH]
  • |Sarcoma/*classification/metabolism/pathology [MESH]
  • |Survival Analysis [MESH]


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