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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Clin+Pathol
2013 ; 140
(1
): 82-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Dense pattern of embryonal rhabdomyosarcoma, a lesion easily confused with
alveolar rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the
Children s Oncology Group
#MMPMID23765537
Rudzinski ER
; Teot LA
; Anderson JR
; Moore J
; Bridge JA
; Barr FG
; Gastier-Foster JM
; Skapek SX
; Hawkins DS
; Parham DM
Am J Clin Pathol
2013[Jul]; 140
(1
): 82-90
PMID23765537
show ga
OBJECTIVES: To examine whether the frequency of fusion-negative alveolar
rhabdomyosarcoma (ARMSn) increased coincident with changes in the definition of
alveolar histology. METHODS: We re-reviewed alveolar rhabdomyosarcoma (ARMS) in
the Children's Oncology Group study D9803, comparing histopathology with fusion
status. RESULTS: Our review of 255 original ARMS cases (compared with a control
group of 38 embryonal rhabdomyosarcomas [ERMS] cases) revealed that many had an
ARMS-like densely cellular pattern with cytologic features and myogenin
expression more typical of ERMS. Following re-review, 84 (33%) cases of original
ARMS were rediagnosed as ERMS. All reclassified ERMS, including dense ERMS, were
fusion negative, whereas 82% of confirmed ARMS cases were fusion positive. Total
ARMS diagnoses returned to historic rates of 25% to 30% of all rhabdomyosarcomas,
and ARMSn decreased from 37% to 18% of ARMS cases. The outcome of reclassified
ERMS was similar to confirmed ERMS. CONCLUSIONS: To address the role of fusion
status in risk stratification, pathologists should include both a histologic
diagnosis and an evaluation of fusion status for all new ARMS diagnoses.