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10.1021/acs.jmedchem.5b00571 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.5b00571 C4624220!4624220 !26177091     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26177091 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Chem 2015 ; 58 (15 ): 6002-17 Nephropedia Template TP {{tp|p=26177091 |t=2015. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for ?-Synuclein Fibrils |pdf=|usr=}}{{26177091 }} gab.com Text Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for -Synuclein Fibrils JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26177091 #FOAvip A series of 3-(benzylidine)indolin-2-one derivatives were synthesized and evaluated for their in vitro binding to alpha synuclein (?-syn), beta amyloid (A?), and tau fibrils. Compounds with a single double bond in the 3-position had only a modest affinity for ?-syn and no selectivity for ?-syn versus A? or tau fibrils. Homologation to the corresponding diene analogues yielded a mixture of Z,E and E,E isomers; substitution of the indoline nitrogen with an N-benzyl group resulted in increased binding to ?-syn and reasonable selectivity for ?-syn versus A? and tau. Introduction of a para-nitro group into the benzene ring of the diene enabled separation of the Z,E and E,E isomers and led to the identification of the Z,E configuration as the more active regioisomer. The data described here provide key structural information in the design of probes which bind preferentially to ?-syn versus A? or tau fibrils. Twit Text FOAVip Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for -Synuclein Fibrils ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26177091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26177091 #FOAvip English Wikipedia <ref>{{Cite pmid|26177091 }}</ref> Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for ?-Synuclein Fibrils #MMPMID26177091 Chu W ; Zhou D ; Gaba V ; Liu J ; Li S ; Peng X ; Xu J ; Dhavale D ; Bagchi DP ; d'Avignon A ; Shakerdge NB ; Bacskai BJ ; Tu Z ; Kotzbauer PT ; Mach RH J Med Chem 2015[Aug]; 58 (15 ): 6002-17 PMID26177091 show ga A series of 3-(benzylidine)indolin-2-one derivatives were synthesized and evaluated for their in vitro binding to alpha synuclein (?-syn), beta amyloid (A?), and tau fibrils. Compounds with a single double bond in the 3-position had only a modest affinity for ?-syn and no selectivity for ?-syn versus A? or tau fibrils. Homologation to the corresponding diene analogues yielded a mixture of Z,E and E,E isomers; substitution of the indoline nitrogen with an N-benzyl group resulted in increased binding to ?-syn and reasonable selectivity for ?-syn versus A? and tau. Introduction of a para-nitro group into the benzene ring of the diene enabled separation of the Z,E and E,E isomers and led to the identification of the Z,E configuration as the more active regioisomer. The data described here provide key structural information in the design of probes which bind preferentially to ?-syn versus A? or tau fibrils. |*Drug Design [MESH] |Indoles/chemical synthesis/*chemistry [MESH] |Ligands [MESH] |Microscopy, Fluorescence [MESH]Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-on(epmc).pdf DeepDyve Pubget Overpricing