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2011 ; 51
(1
): 26-38
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Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in
health and disease
#MMPMID21626285
Basu S
; Dittel BN
Immunol Res
2011[Oct]; 51
(1
): 26-38
PMID21626285
show ga
It has become clear that the endocannabinoid system is a potent regulator of
immune responses, with the cannabinoid receptor 2 (CB2) as the key component due
to its high expression by all immune subtypes. CB2 has been shown to regulate
immunity by a number of mechanisms including development, migration,
proliferation, and effector functions. In addition, CB2 has been shown to
modulate the function of all immune cell types examined to date. CB2 is a
G(i)-protein-coupled receptor and thus exhibits a complex pharmacology allowing
both stimulatory and inhibitory signaling that depends on receptor expression
levels, ligand concentration, and cell lineage specificities. Here, we discuss
both in vitro and in vivo experimental evidence that CB2 is a potent regulator of
immune responses making it a prime target for the treatment of inflammatory
diseases.