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10.1016/j.ddmec.2013.03.001 http://scihub22266oqcxt.onion/10.1016/j.ddmec.2013.03.001 C4624194!4624194!26523147     free     free     free       Drug+Discov+Today+Dis+Mech 2013 ; 10 (3-4): e113-8 Nephropedia Template TP {{tp|p=26523147|t=2013. STAT3 Signaling in Polycystic Kidney Disease |pdf=|usr=}}{{26523147}} gab.com Text STAT3 Signaling in Polycystic Kidney Disease JO: Drug Discov Today Dis Mech http://www.kidney.de/pget.php?&tw=1&pmid=26523147 #FOAvip Mutations in the gene coding for the integral membrane protein polycystin-1 (PC1) are the cause of most cases of autosomal-dominant polycystic kidney disease (ADPKD), a very common disease that leads to kidney failure and currently lacks approved treatment. Recent work has revealed that PC1 can regulate the transcription factor STAT3, and that STAT3 is aberrantly activated in the kidneys of ADPKD patients and PKD mouse models. Recent approaches to directly inhibit STAT3 in PKD mouse models have been promising. Numerous signaling pathways are known to activate STAT3 and many have long been implicated in the pathogenesis of PKD - such as EGF/EGFR, HGF/c-Met, Src. However, a role of STAT3 in the pathogenesis of PKD had never been considered until now. Here, we review the current findings that suggest that STAT3 is a promising target for the treatment of PKD. Twit Text FOAVip STAT3 Signaling in Polycystic Kidney Disease ????Drug Discov Today Dis Mech http://www.kidney.de/pget.php?&tw=1&pmid=26523147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26523147 #FOAvip English Wikipedia <ref>{{Cite pmid|26523147}}</ref> STAT3 Signaling in Polycystic Kidney Disease #MMPMID26523147 Weimbs T; Talbot JJ Drug Discov Today Dis Mech 2013[Dec]; 10 (3-4): e113-8 PMID26523147show ga Mutations in the gene coding for the integral membrane protein polycystin-1 (PC1) are the cause of most cases of autosomal-dominant polycystic kidney disease (ADPKD), a very common disease that leads to kidney failure and currently lacks approved treatment. Recent work has revealed that PC1 can regulate the transcription factor STAT3, and that STAT3 is aberrantly activated in the kidneys of ADPKD patients and PKD mouse models. Recent approaches to directly inhibit STAT3 in PKD mouse models have been promising. Numerous signaling pathways are known to activate STAT3 and many have long been implicated in the pathogenesis of PKD - such as EGF/EGFR, HGF/c-Met, Src. However, a role of STAT3 in the pathogenesis of PKD had never been considered until now. Here, we review the current findings that suggest that STAT3 is a promising target for the treatment of PKD. äSTAT3 Signaling in Polycystic Kidney Disease (epmc).pdf DeepDyve Pubget Overpricing