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10.1016/j.jconrel.2015.08.031 http://scihub22266oqcxt.onion/10.1016/j.jconrel.2015.08.031 C4624027!4624027 !26302903     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26302903 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Control+Release 2015 ; 217 (ä): 42-52 Nephropedia Template TP {{tp|p=26302903 |t=2015. Delivery of siRNA via cationic Sterosomes to enhance osteogenic differentiation of mesenchymal stem cells |pdf=|usr=}}{{26302903 }} gab.com Text Delivery of siRNA via cationic Sterosomes to enhance osteogenic differentiation of mesenchymal stem cells JO: J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=26302903 #FOAvip Noggin is a specific antagonist of bone morphogenetic proteins (BMPs) that can prevent the interaction of BMPs with their receptors. RNA interfering molecules have been used to downregulate noggin expression and thereby stimulate BMP signaling and osteogenesis. Cationic liposomes are considered one of the most efficient non-viral systems for gene delivery. In the past decade, non-phospholipid liposomes (Sterosomes) formulated with single-chain amphiphiles and high content of sterols have been developed. In particular, Sterosomes composed of stearylamine (SA) and cholesterol (Chol) display distinct properties compared with traditional phospholipid liposomes, including increased positive surface charges and enhanced particle stability. Herein, we report SA/Chol Sterosome and small interfering RNA (siRNA) complexes that significantly enhanced cellular uptake and gene knockdown efficiencies in adipose derived mesenchymal stem cells with minimal cytotoxicity compared with commercially available lipofectamine 2000. Furthermore, we confirmed osteogenic efficacy of these Sterosomes loaded with noggin siRNA in in vitro two- and three-dimensional settings as well as in a mouse calvarial defect model. The delivery of siRNA via novel SA/Chol Sterosomes presents a powerful method for efficient gene knockdown. These distinct nanoparticles may present a promising alternative approach for gene delivery. Twit Text FOAVip Delivery of siRNA via cationic Sterosomes to enhance osteogenic differentiation of mesenchymal stem cells ????J Control Release http://www.kidney.de/pget.php?&tw=1&pmid=26302903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26302903 #FOAvip English Wikipedia <ref>{{Cite pmid|26302903 }}</ref> Delivery of siRNA via cationic Sterosomes to enhance osteogenic differentiation of mesenchymal stem cells #MMPMID26302903 Cui ZK ; Fan J ; Kim S ; Bezouglaia O ; Fartash A ; Wu BM ; Aghaloo T ; Lee M J Control Release 2015[Nov]; 217 (ä): 42-52 PMID26302903 show ga Noggin is a specific antagonist of bone morphogenetic proteins (BMPs) that can prevent the interaction of BMPs with their receptors. RNA interfering molecules have been used to downregulate noggin expression and thereby stimulate BMP signaling and osteogenesis. Cationic liposomes are considered one of the most efficient non-viral systems for gene delivery. In the past decade, non-phospholipid liposomes (Sterosomes) formulated with single-chain amphiphiles and high content of sterols have been developed. In particular, Sterosomes composed of stearylamine (SA) and cholesterol (Chol) display distinct properties compared with traditional phospholipid liposomes, including increased positive surface charges and enhanced particle stability. Herein, we report SA/Chol Sterosome and small interfering RNA (siRNA) complexes that significantly enhanced cellular uptake and gene knockdown efficiencies in adipose derived mesenchymal stem cells with minimal cytotoxicity compared with commercially available lipofectamine 2000. Furthermore, we confirmed osteogenic efficacy of these Sterosomes loaded with noggin siRNA in in vitro two- and three-dimensional settings as well as in a mouse calvarial defect model. The delivery of siRNA via novel SA/Chol Sterosomes presents a powerful method for efficient gene knockdown. These distinct nanoparticles may present a promising alternative approach for gene delivery. |*Gene Transfer Techniques [MESH] |*Osteogenesis [MESH] |Adipose Tissue/cytology [MESH] |Amines/chemistry [MESH] |Animals [MESH] |Carrier Proteins/*genetics [MESH] |Cell Differentiation [MESH] |Chitosan/analogs & derivatives/chemistry [MESH] |Cholesterol/chemistry [MESH] |Gene Silencing [MESH] |Hydrogels/chemistry [MESH] |Liposomes [MESH] |Male [MESH] |Mesenchymal Stem Cells/*cytology/drug effects [MESH] |Mice, Inbred C57BL [MESH] |Mice, Nude [MESH] |Nanoparticles/administration & dosage/toxicity [MESH] |RNA, Small Interfering/*administration & dosage/chemistry [MESH] |Radiography [MESH]Delivery of siRNA via cationic Sterosomes to enhance osteogenic differ(epmc).pdf DeepDyve Pubget Overpricing