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10.1186/s12879-015-1143-1 http://scihub22266oqcxt.onion/10.1186/s12879-015-1143-1 C4623895!4623895 !26503366     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26503366 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis |pdf=|usr=}}{{26503366 }} gab.com Text Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=26503366 #FOAvip BACKGROUND: Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for Clinical Microbiology and Infectious Diseases strongly recommend echinocandins for the first-line treatment of C/IC. Here, a cost-effectiveness model was developed from the United Kingdom perspective to examine the costs and outcomes of antifungal treatment for C/IC based on the European Society for Clinical Microbiology and Infectious Diseases guidelines. METHODS: Costs and treatment outcomes with the echinocandin anidulafungin were compared with those for caspofungin, micafungin and fluconazole. The model included non-neutropenic patients aged ?16 years with confirmed C/IC who were receiving intravenous first-line treatment. Patients were categorised as either a clinical success or failure (patients with persistent/breakthrough infection); successfully treated patients switched to oral therapy, while patients categorised as clinical failures switched to a different antifungal class. Other inputs were all-cause mortality at 6 weeks, costs of treatment-related adverse events and other medical resource utilisation costs. Resource use was derived from the published literature and from discussion with clinical experts. Drug-acquisition/administration costs were taken from standard United Kingdom costing sources. RESULTS: The model indicated that first-line anidulafungin could be considered cost-effective versus fluconazole (incremental cost-effectiveness ratio £813 per life-year gained) for the treatment of C/IC. Anidulafungin was cost-saving versus caspofungin and micafungin due to lower total costs and a higher rate of survival combined with a higher probability of clinical success. DISCUSSION: European Society for Clinical Microbiology and Infectious Diseases guidelines recommend echinocandins for the first-line treatment of C/IC; our model indicated that anidulafungin marries clinical effectiveness and cost-effectiveness. CONCLUSIONS: From the United Kingdom perspective, anidulafungin was cost-effective compared with fluconazole for the treatment of C/IC and was cost-saving versus the other echinocandins. Twit Text FOAVip Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=26503366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26503366 #FOAvip English Wikipedia <ref>{{Cite pmid|26503366 }}</ref> Cost-effectiveness analysis of anidulafungin for the treatment of candidaemia and other forms of invasive candidiasis #MMPMID26503366 Auzinger G ; Playford EG ; Graham CN ; Knox HN ; Weinstein D ; Kantecki M ; Schlamm H ; Charbonneau C BMC Infect Dis 2015[Oct]; 15 (ä): 463 PMID26503366 show ga BACKGROUND: Candidaemia and other forms of invasive candidiasis (C/IC) in the intensive care unit are challenging conditions that are associated with high rates of mortality. New guidelines from the European Society for Clinical Microbiology and Infectious Diseases strongly recommend echinocandins for the first-line treatment of C/IC. Here, a cost-effectiveness model was developed from the United Kingdom perspective to examine the costs and outcomes of antifungal treatment for C/IC based on the European Society for Clinical Microbiology and Infectious Diseases guidelines. METHODS: Costs and treatment outcomes with the echinocandin anidulafungin were compared with those for caspofungin, micafungin and fluconazole. The model included non-neutropenic patients aged ?16 years with confirmed C/IC who were receiving intravenous first-line treatment. Patients were categorised as either a clinical success or failure (patients with persistent/breakthrough infection); successfully treated patients switched to oral therapy, while patients categorised as clinical failures switched to a different antifungal class. Other inputs were all-cause mortality at 6 weeks, costs of treatment-related adverse events and other medical resource utilisation costs. Resource use was derived from the published literature and from discussion with clinical experts. Drug-acquisition/administration costs were taken from standard United Kingdom costing sources. RESULTS: The model indicated that first-line anidulafungin could be considered cost-effective versus fluconazole (incremental cost-effectiveness ratio £813 per life-year gained) for the treatment of C/IC. Anidulafungin was cost-saving versus caspofungin and micafungin due to lower total costs and a higher rate of survival combined with a higher probability of clinical success. DISCUSSION: European Society for Clinical Microbiology and Infectious Diseases guidelines recommend echinocandins for the first-line treatment of C/IC; our model indicated that anidulafungin marries clinical effectiveness and cost-effectiveness. CONCLUSIONS: From the United Kingdom perspective, anidulafungin was cost-effective compared with fluconazole for the treatment of C/IC and was cost-saving versus the other echinocandins. |Anidulafungin [MESH] |Antifungal Agents/adverse effects/economics/therapeutic use [MESH] |Candidemia/drug therapy [MESH] |Candidiasis, Invasive/*drug therapy/economics/mortality [MESH] |Caspofungin [MESH] |Cost-Benefit Analysis [MESH] |Drug Costs [MESH] |Echinocandins/*economics/*therapeutic use [MESH] |Fluconazole/economics/therapeutic use [MESH] |Humans [MESH] |Intensive Care Units/economics [MESH] |Length of Stay/economics [MESH] |Lipopeptides/economics/therapeutic use [MESH] |Micafungin [MESH] |Models, Economic [MESH] |Treatment Outcome [MESH]Cost-effectiveness analysis of anidulafungin for the treatment of cand(epmc).pdf DeepDyve Pubget Overpricing