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10.1080/15384047.2015.1026482 http://scihub22266oqcxt.onion/10.1080/15384047.2015.1026482 C4623043!4623043!25803193     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Biol+Ther 2015 ; 16 (5): 799-806 Nephropedia Template TP {{tp|p=25803193|t=2015. PRIMA-1Met induces apoptosis in Waldenström s Macroglobulinemia cells independent of p53 |pdf=|usr=}}{{25803193}} gab.com Text PRIMA-1Met induces apoptosis in Waldenström s Macroglobulinemia cells independent of p53 JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25803193 #FOAvip PRIMA-1Met has shown promising preclinical activity in various cancer types. However, its effect on Waldenström's Macroglobulinemia (WM) cells as well as its exact mechanism of action is still elusive. In this study, we evaluated the anti- tumor activity of PRIMA-1Met alone and in combination with dexamethasone or bortezomib in WM cell lines and primary samples. Treatment of WM cells with PRIMA-1Met resulted in induction of apoptosis, inhibition of migration and suppression of colony formation. Upon PRIMA-1Met treatment, p73 was upregulated and Bcl-xL was down-regulated while no significant change in expression of p53 was observed. Furthermore, siRNA knockdown of p53 in WM cell line did not influence the PRIMA-1Met-induced apoptotic response whereas silencing of p73 inhibited latter response in WM cells. Importantly, combined treatment of BCWM-1 cells with PRIMA-1Met and dexamethasone or bortezomib induced synergistic reduction in cell survival. Our study provides insights into the mechanisms of anti-WM activity of PRIMA-1Met and supports further clinical evaluation of PRIMA-1Met as a potential novel therapeutic intervention in WM. Twit Text FOAVip PRIMA-1Met induces apoptosis in Waldenström s Macroglobulinemia cells independent of p53 ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25803193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25803193 #FOAvip English Wikipedia <ref>{{Cite pmid|25803193}}</ref> PRIMA-1Met induces apoptosis in Waldenström s Macroglobulinemia cells independent of p53 #MMPMID25803193 Sobhani M; Abdi J; Manujendra SN; Chen C; Chang H Cancer Biol Ther 2015[May]; 16 (5): 799-806 PMID25803193show ga PRIMA-1Met has shown promising preclinical activity in various cancer types. However, its effect on Waldenström's Macroglobulinemia (WM) cells as well as its exact mechanism of action is still elusive. In this study, we evaluated the anti- tumor activity of PRIMA-1Met alone and in combination with dexamethasone or bortezomib in WM cell lines and primary samples. Treatment of WM cells with PRIMA-1Met resulted in induction of apoptosis, inhibition of migration and suppression of colony formation. Upon PRIMA-1Met treatment, p73 was upregulated and Bcl-xL was down-regulated while no significant change in expression of p53 was observed. Furthermore, siRNA knockdown of p53 in WM cell line did not influence the PRIMA-1Met-induced apoptotic response whereas silencing of p73 inhibited latter response in WM cells. Importantly, combined treatment of BCWM-1 cells with PRIMA-1Met and dexamethasone or bortezomib induced synergistic reduction in cell survival. Our study provides insights into the mechanisms of anti-WM activity of PRIMA-1Met and supports further clinical evaluation of PRIMA-1Met as a potential novel therapeutic intervention in WM. äPRIMA-1Met induces apoptosis in Waldenström s Macroglobulinemia cells (epmc).pdf DeepDyve Pubget Overpricing