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10.1080/15592294.2015.1040619 http://scihub22266oqcxt.onion/10.1080/15592294.2015.1040619 C4623031!4623031 !25880792     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25880792 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Epigenetics 2015 ; 10 (6 ): 484-95 Nephropedia Template TP {{tp|p=25880792 |t=2015. Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes |pdf=|usr=}}{{25880792 }} gab.com Text Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25880792 #FOAvip Although age-associated gene expression and methylation changes have been reported throughout the literature, the unifying epigenomic principles of aging remain poorly understood. Recent explosion in availability and resolution of functional/regulatory genome annotation data (epigenomic data), such as that provided by the ENCODE and Roadmap Epigenomics projects, provides an opportunity for the identification of epigenomic mechanisms potentially altered by age-associated differentially methylated regions (aDMRs) and regulatory signatures in the promoters of age-associated genes (aGENs). In this study we found that aDMRs and aGENs identified in multiple independent studies share a common Polycomb Repressive Complex 2 signature marked by EZH2, SUZ12, CTCF binding sites, repressive H3K27me3, and activating H3K4me1 histone modification marks, and a "poised promoter" chromatin state. This signature is depleted in RNA Polymerase II-associated transcription factor binding sites, activating H3K79me2, H3K36me3, H3K27ac marks, and an "active promoter" chromatin state. The PRC2 signature was shown to be generally stable across cell types. When considering the directionality of methylation changes, we found the PRC2 signature to be associated with aDMRs hypermethylated with age, while hypomethylated aDMRs were associated with enhancers. In contrast, aGENs were associated with the PRC2 signature independently of the directionality of gene expression changes. In this study we demonstrate that the PRC2 signature is the common epigenomic context of genomic regions associated with hypermethylation and gene expression changes in aging. Twit Text FOAVip Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25880792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25880792 #FOAvip English Wikipedia <ref>{{Cite pmid|25880792 }}</ref> Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes #MMPMID25880792 Dozmorov MG Epigenetics 2015[]; 10 (6 ): 484-95 PMID25880792 show ga Although age-associated gene expression and methylation changes have been reported throughout the literature, the unifying epigenomic principles of aging remain poorly understood. Recent explosion in availability and resolution of functional/regulatory genome annotation data (epigenomic data), such as that provided by the ENCODE and Roadmap Epigenomics projects, provides an opportunity for the identification of epigenomic mechanisms potentially altered by age-associated differentially methylated regions (aDMRs) and regulatory signatures in the promoters of age-associated genes (aGENs). In this study we found that aDMRs and aGENs identified in multiple independent studies share a common Polycomb Repressive Complex 2 signature marked by EZH2, SUZ12, CTCF binding sites, repressive H3K27me3, and activating H3K4me1 histone modification marks, and a "poised promoter" chromatin state. This signature is depleted in RNA Polymerase II-associated transcription factor binding sites, activating H3K79me2, H3K36me3, H3K27ac marks, and an "active promoter" chromatin state. The PRC2 signature was shown to be generally stable across cell types. When considering the directionality of methylation changes, we found the PRC2 signature to be associated with aDMRs hypermethylated with age, while hypomethylated aDMRs were associated with enhancers. In contrast, aGENs were associated with the PRC2 signature independently of the directionality of gene expression changes. In this study we demonstrate that the PRC2 signature is the common epigenomic context of genomic regions associated with hypermethylation and gene expression changes in aging. |*Epigenomics [MESH] |Aging/*genetics/pathology [MESH] |Binding Sites [MESH] |CCCTC-Binding Factor [MESH] |Cell Line [MESH] |Chromatin/genetics [MESH] |DNA Methylation/*genetics [MESH] |Enhancer of Zeste Homolog 2 Protein [MESH] |Gene Expression Regulation [MESH] |Histones/genetics [MESH] |Humans [MESH] |Neoplasm Proteins [MESH] |Polycomb Repressive Complex 2/*genetics/metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |Protein Structure, Tertiary [MESH] |Repressor Proteins/genetics [MESH]Polycomb repressive complex 2 epigenomic signature defines age-associa(epmc).pdf DeepDyve Pubget Overpricing