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10.4161/15592294.2014.970077 http://scihub22266oqcxt.onion/10.4161/15592294.2014.970077 C4622968!4622968!25437056     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics 2014 ; 9 (10): 1422-30 Nephropedia Template TP {{tp|p=25437056|t=2014. Altered promoter nucleosome positioning is an early event in gene silencing |pdf=|usr=}}{{25437056}} gab.com Text Altered promoter nucleosome positioning is an early event in gene silencing JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25437056 #FOAvip Gene silencing in cancer frequently involves hypermethylation and dense nucleosome occupancy across promoter regions. How a promoter transitions to this silent state is unclear. Using colorectal adenomas, we investigated nucleosome positioning, DNA methylation, and gene expression in the early stages of gene silencing. Genome-wide gene expression correlated with highly positioned nucleosomes upstream and downstream of a nucleosome-depleted transcription start site (TSS). Hypermethylated promoters displayed increased nucleosome occupancy, specifically at the TSS. We investigated 2 genes, CDH1 and CDKN2B, which were silenced in adenomas but lacked promoter hypermethylation. Instead, silencing correlated with loss of nucleosomes from the -2 position upstream of the TSS relative to normal mucosa. In contrast, permanent CDH1 silencing in carcinoma cells was characterized by promoter hypermethylation and dense nucleosome occupancy. Our findings suggest that silenced genes transition through an intermediary stage involving altered promoter nucleosome positioning, before permanent silencing by hypermethylation and dense nucleosome occupancy. Twit Text FOAVip Altered promoter nucleosome positioning is an early event in gene silencing ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=25437056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25437056 #FOAvip English Wikipedia <ref>{{Cite pmid|25437056}}</ref> Altered promoter nucleosome positioning is an early event in gene silencing #MMPMID25437056 Hesson LB; Sloane MA; Wong JW; Nunez AC; Srivastava S; Ng B; Hawkins NJ; Bourke MJ; Ward RL Epigenetics 2014[Oct]; 9 (10): 1422-30 PMID25437056show ga Gene silencing in cancer frequently involves hypermethylation and dense nucleosome occupancy across promoter regions. How a promoter transitions to this silent state is unclear. Using colorectal adenomas, we investigated nucleosome positioning, DNA methylation, and gene expression in the early stages of gene silencing. Genome-wide gene expression correlated with highly positioned nucleosomes upstream and downstream of a nucleosome-depleted transcription start site (TSS). Hypermethylated promoters displayed increased nucleosome occupancy, specifically at the TSS. We investigated 2 genes, CDH1 and CDKN2B, which were silenced in adenomas but lacked promoter hypermethylation. Instead, silencing correlated with loss of nucleosomes from the -2 position upstream of the TSS relative to normal mucosa. In contrast, permanent CDH1 silencing in carcinoma cells was characterized by promoter hypermethylation and dense nucleosome occupancy. Our findings suggest that silenced genes transition through an intermediary stage involving altered promoter nucleosome positioning, before permanent silencing by hypermethylation and dense nucleosome occupancy. äAltered promoter nucleosome positioning is an early event in gene sile(epmc).pdf DeepDyve Pubget Overpricing