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10.1080/15384047.2015.1016662 http://scihub22266oqcxt.onion/10.1080/15384047.2015.1016662 C4622741!4622741!25781910     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Biol+Ther 2015 ; 16 (3): 353-9 Nephropedia Template TP {{tp|p=25781910|t=2015. Hes1: a key role in stemness, metastasis and multidrug resistance |pdf=|usr=}}{{25781910}} gab.com Text Hes1: a key role in stemness, metastasis and multidrug resistance JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25781910 #FOAvip Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs), metastasis and antagonizing drug-induced apoptosis. Pathways that are involved in the up-regulation of Hes1 level canonically or non-canonically, such as the Hedgehog, Wnt and hypoxia pathways are frequently aberrant in cancer cells. Here, we summarize the recent data supporting the idea that Hes1 may have an important function in the maintenance of cancer stem cells self-renewal, cancer metastasis, and epithelial?mesenchymal transition (EMT) process induction, as well as chemotherapy resistance, and conclude with the possible mechanisms by which Hes1 functions have their effect, as well as their crosstalk with other carcinogenic signaling pathways. Twit Text FOAVip Hes1: a key role in stemness, metastasis and multidrug resistance ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=25781910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25781910 #FOAvip English Wikipedia <ref>{{Cite pmid|25781910}}</ref> Hes1: a key role in stemness, metastasis and multidrug resistance #MMPMID25781910 Liu ZH; Dai XM; Du B Cancer Biol Ther 2015[Mar]; 16 (3): 353-9 PMID25781910show ga Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs), metastasis and antagonizing drug-induced apoptosis. Pathways that are involved in the up-regulation of Hes1 level canonically or non-canonically, such as the Hedgehog, Wnt and hypoxia pathways are frequently aberrant in cancer cells. Here, we summarize the recent data supporting the idea that Hes1 may have an important function in the maintenance of cancer stem cells self-renewal, cancer metastasis, and epithelial?mesenchymal transition (EMT) process induction, as well as chemotherapy resistance, and conclude with the possible mechanisms by which Hes1 functions have their effect, as well as their crosstalk with other carcinogenic signaling pathways. äHes1: a key role in stemness, metastasis and multidrug resistance (epmc).pdf DeepDyve Pubget Overpricing