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10.5966/sctm.2015-0062

http://scihub22266oqcxt.onion/10.5966/sctm.2015-0062
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suck abstract from ncbi


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pmid26359426      Stem+Cells+Transl+Med 2015 ; 4 (11): 1265-74
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  • Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis #MMPMID26359426
  • Henry E; Cores J; Hensley MT; Anthony S; Vandergriff A; de Andrade JB; Allen T; Caranasos TG; Lobo LJ; Cheng K
  • Stem Cells Transl Med 2015[Nov]; 4 (11): 1265-74 PMID26359426show ga
  • A rapid and robust method to generate therapeutic resident lung progenitors from adult lung tissues is reported. Outgrowth cells from healthy lung explants were self-aggregated into three-dimensional lung spheroids. Lung spheroid cells inhibited apoptosis, fibrosis, and infiltration but promoted angiogenesis and outperformed adipose-derived mesenchymal stem cells, suggesting that lung spheroids and lung spheroid cells from healthy lung tissues are excellent sources of regenerative lung cells for therapeutic lung regeneration.
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