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10.11613/BM.2015.043

http://scihub22266oqcxt.onion/10.11613/BM.2015.043
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C4622198!4622198!26527485
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suck abstract from ncbi


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pmid26527485      Biochem+Med+(Zagreb) 2015 ; 25 (3): 421-9
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  • ?Real life use? of troponin in the emergency department: a survey of over 3000 cases #MMPMID26527485
  • Vidali M; Verzotti E; Cabraz N; Santi F; Puma A; Bellomo G; Lupi A; Lippi G; Avanzi GC
  • Biochem Med (Zagreb) 2015[Oct]; 25 (3): 421-9 PMID26527485show ga
  • Introduction: The aim of this study was to identify clinical variables which may be independently associated with positivity of a cardiac troponin I (cTnI) assay in a large population of patients admitted to the emergency department (ED). Materials and methods: 3166 subjects, with at least two troponin I tests ordered within 6 hours in the ED, were studied. Patient data were statistically analyzed to identify clinical associations with increased values of Troponin I. Results: Although patients with diagnosis of acute coronary syndrome displayed troponin I values significantly higher than those of other groups, positivity to troponin I (> 40 ng/L) was also observed in patients with other clinical conditions. In multivariate analysis, age, elevated heart rate and electrocardiographyc changes were independently associated with troponin I positivity at admission. In the whole study population troponin I positivity exhibited high sensitivity and negative predictive value, counterbalanced by low specificity and limited positive predictive value. Conclusions: Troponin I positivity should be combined with history and clinical evaluation and cautiously interpreted in the ED, especially in patients exhibiting factors associated with higher troponin I levels such as older age, elevated heart rate or ECG changes.
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