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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Infect+Dis 2015 ; 15 (ä): ä Nephropedia Template TP
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Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection #MMPMID26503619
Bunz H; Weyrich P; Peter A; Baumann D; Tschritter O; Guthoff M; Beck R; Jahn G; Artunc F; Häring HU; Heyne N; Wagner R
BMC Infect Dis 2015[]; 15 (ä): ä PMID26503619show ga
Background: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial number of previously healthy individuals developing acute kidney injury (AKI). There is a considerable diversity in the clinical course of the disease, and few patients require renal replacement therapy. Methods: We tested whether urinary neutrophil gelatinase associated lipocalin (uNGAL), urine albumin/creatinine ratio (uACR), urine protein/creatinine ratio (uPCR), urine dipstick protein, C-reactive protein, procalcitonin, leukocyte and platelet count, determined on admission to the hospital, can predict the severity of AKI. Sixty-one patients were analyzed during admission in the emergency department. Results: The variables most strongly associated with peak plasma creatinine concentration were uNGAL (??=?0.70, p <0.0001), uPCR (??=?0.64, p?=?0.001), uACR (??=?0.61, p?=?0.002), and dipstick proteinuria (??=?0.34, p?=?0.008). The highest AUC-ROC to predict stage 3 AKI according to the acute kidney injury network?s (AKIN) classification was seen for uNGAL (0.81, p?=?0.001). Conclusion: uNGAL accurately predicts the severity of AKI in NE. This could help emergency room physicians predict disease severity and allow for initial risk stratification. Electronic supplementary material: The online version of this article (doi:10.1186/s12879-015-1180-9) contains supplementary material, which is available to authorized users.