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10.1186/s12879-015-1180-9 http://scihub22266oqcxt.onion/10.1186/s12879-015-1180-9 C4621931!4621931 !26503619     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26503619 &cmd=llinks): Failed to open stream: HTTP request failed! 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Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection |pdf=|usr=}}{{26503619 }} gab.com Text Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=26503619 #FOAvip BACKGROUND: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial number of previously healthy individuals developing acute kidney injury (AKI). There is a considerable diversity in the clinical course of the disease, and few patients require renal replacement therapy. METHODS: We tested whether urinary neutrophil gelatinase associated lipocalin (uNGAL), urine albumin/creatinine ratio (uACR), urine protein/creatinine ratio (uPCR), urine dipstick protein, C-reactive protein, procalcitonin, leukocyte and platelet count, determined on admission to the hospital, can predict the severity of AKI. Sixty-one patients were analyzed during admission in the emergency department. RESULTS: The variables most strongly associated with peak plasma creatinine concentration were uNGAL (? = 0.70, p <0.0001), uPCR (? = 0.64, p = 0.001), uACR (? = 0.61, p = 0.002), and dipstick proteinuria (? = 0.34, p = 0.008). The highest AUC-ROC to predict stage 3 AKI according to the acute kidney injury network's (AKIN) classification was seen for uNGAL (0.81, p = 0.001). CONCLUSION: uNGAL accurately predicts the severity of AKI in NE. This could help emergency room physicians predict disease severity and allow for initial risk stratification. Twit Text FOAVip Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=26503619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26503619 #FOAvip English Wikipedia <ref>{{Cite pmid|26503619 }}</ref> Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection #MMPMID26503619 Bunz H ; Weyrich P ; Peter A ; Baumann D ; Tschritter O ; Guthoff M ; Beck R ; Jahn G ; Artunc F ; Häring HU ; Heyne N ; Wagner R BMC Infect Dis 2015[Oct]; 15 (ä): 464 PMID26503619 show ga BACKGROUND: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial number of previously healthy individuals developing acute kidney injury (AKI). There is a considerable diversity in the clinical course of the disease, and few patients require renal replacement therapy. METHODS: We tested whether urinary neutrophil gelatinase associated lipocalin (uNGAL), urine albumin/creatinine ratio (uACR), urine protein/creatinine ratio (uPCR), urine dipstick protein, C-reactive protein, procalcitonin, leukocyte and platelet count, determined on admission to the hospital, can predict the severity of AKI. Sixty-one patients were analyzed during admission in the emergency department. RESULTS: The variables most strongly associated with peak plasma creatinine concentration were uNGAL (? = 0.70, p <0.0001), uPCR (? = 0.64, p = 0.001), uACR (? = 0.61, p = 0.002), and dipstick proteinuria (? = 0.34, p = 0.008). The highest AUC-ROC to predict stage 3 AKI according to the acute kidney injury network's (AKIN) classification was seen for uNGAL (0.81, p = 0.001). CONCLUSION: uNGAL accurately predicts the severity of AKI in NE. This could help emergency room physicians predict disease severity and allow for initial risk stratification. |Acute Kidney Injury/etiology/urine/virology [MESH] |Acute-Phase Proteins/*urine [MESH] |Adult [MESH] |Albuminuria/etiology [MESH] |Biomarkers/blood/urine [MESH] |C-Reactive Protein/analysis [MESH] |Calcitonin [MESH] |Calcitonin Gene-Related Peptide [MESH] |Creatinine/blood [MESH] |Emergency Service, Hospital [MESH] |Female [MESH] |Hemorrhagic Fever with Renal Syndrome/*etiology/virology [MESH] |Humans [MESH] |Lipocalin-2 [MESH] |Lipocalins/*urine [MESH] |Male [MESH] |Middle Aged [MESH] |Protein Precursors [MESH] |Proteinuria/*etiology [MESH] |Proto-Oncogene Proteins/*urine [MESH] |Puumala virus/*pathogenicity [MESH]Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinu(epmc).pdf DeepDyve Pubget Overpricing