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10.18632/oncotarget.4329 http://scihub22266oqcxt.onion/10.18632/oncotarget.4329 C4621913!4621913 !26087195     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26087195 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (21 ): 18602-12 Nephropedia Template TP {{tp|p=26087195 |t=2015. DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer |pdf=|usr=}}{{26087195 }} gab.com Text DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26087195 #FOAvip BACKGROUND: Conflicting results regarding the role of DEAD-box polypeptide 3 (DDX3) are seen not only between cancer types but also within the same type of cancer. In this study, we aimed at clarifying the prognostic significance of DDX3 in patients of major cancer types through large cohort survival analysis and further investigated its effects on cancer progression. METHODS: Large cohort survival analysis of 7 cancer types, including colorectal cancer, breast cancer, lung cancer, head and neck cancer, liver cancer, glioblastoma, and ovarian cancer, was performed using public database at RNA level and was further confirmed by IHC analysis at protein level. Phenotype parameters of DDX3 knockdown colon cancer cells and the mechanism of DDX3 regulated cancer progression were investigated in vitro and in vivo. RESULTS: In large cohort survival analysis, DDX3 had a significant prognostic predictive power in colorectal cancer at both RNA and protein level. Patients with low DDX3 expression had poor prognosis and frequent distant metastasis. Knockdown of DDX3 enhanced the migration and invasion abilities of colon cancer cells and promoted tumor metastasis in vivo. Snail upregulation with decreased membranous E-cadherin expression and reduced cell aggregation were found after DDX3 downregulation. CONCLUSIONS: Our study revealed the strong prognostic effect of DDX3 on colorectal cancer among seven major cancer types through larger cohort survival analysis at RNA and protein level. Low DDX3 expression promotes Snail/E-cadherin pathway mediated cancer metastasis and poor clinical outcome in colorectal cancer patients. Twit Text FOAVip DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26087195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26087195 #FOAvip English Wikipedia <ref>{{Cite pmid|26087195 }}</ref> DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer #MMPMID26087195 Su CY ; Lin TC ; Lin YF ; Chen MH ; Lee CH ; Wang HY ; Lee YC ; Liu YP ; Chen CL ; Hsiao M Oncotarget 2015[Jul]; 6 (21 ): 18602-12 PMID26087195 show ga BACKGROUND: Conflicting results regarding the role of DEAD-box polypeptide 3 (DDX3) are seen not only between cancer types but also within the same type of cancer. In this study, we aimed at clarifying the prognostic significance of DDX3 in patients of major cancer types through large cohort survival analysis and further investigated its effects on cancer progression. METHODS: Large cohort survival analysis of 7 cancer types, including colorectal cancer, breast cancer, lung cancer, head and neck cancer, liver cancer, glioblastoma, and ovarian cancer, was performed using public database at RNA level and was further confirmed by IHC analysis at protein level. Phenotype parameters of DDX3 knockdown colon cancer cells and the mechanism of DDX3 regulated cancer progression were investigated in vitro and in vivo. RESULTS: In large cohort survival analysis, DDX3 had a significant prognostic predictive power in colorectal cancer at both RNA and protein level. Patients with low DDX3 expression had poor prognosis and frequent distant metastasis. Knockdown of DDX3 enhanced the migration and invasion abilities of colon cancer cells and promoted tumor metastasis in vivo. Snail upregulation with decreased membranous E-cadherin expression and reduced cell aggregation were found after DDX3 downregulation. CONCLUSIONS: Our study revealed the strong prognostic effect of DDX3 on colorectal cancer among seven major cancer types through larger cohort survival analysis at RNA and protein level. Low DDX3 expression promotes Snail/E-cadherin pathway mediated cancer metastasis and poor clinical outcome in colorectal cancer patients. |*Gene Expression Regulation, Neoplastic [MESH] |Aged [MESH] |Animals [MESH] |Biomarkers, Tumor/*genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Colorectal Neoplasms/*genetics/metabolism/pathology [MESH] |DEAD-box RNA Helicases/*genetics/metabolism [MESH] |Databases, Genetic [MESH] |Down-Regulation [MESH] |Female [MESH] |HCT116 Cells [MESH] |HT29 Cells [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Mice, Inbred NOD [MESH] |Mice, Knockout [MESH] |Mice, SCID [MESH] |Middle Aged [MESH] |Neoplasm Metastasis [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Prognosis [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Survival Analysis [MESH]DDX3 as a strongest prognosis marker and its downregulation promotes m(epmc).pdf DeepDyve Pubget Overpricing