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10.18632/oncotarget.4089 http://scihub22266oqcxt.onion/10.18632/oncotarget.4089 C4621898!4621898 !26158762     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26158762 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (21 ): 18389-405 Nephropedia Template TP {{tp|p=26158762 |t=2015. MiR-101 targets DUSP1 to regulate the TGF-? secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma |pdf=|usr=}}{{26158762 }} gab.com Text MiR-101 targets DUSP1 to regulate the TGF- secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26158762 #FOAvip Hepatocellular carcinoma (HCC)-associated macrophages accelerate tumor progression via growth factor release. Therefore, tumor-associated macrophages (TAMs)-initiated signaling cascades are potential therapeutic targets. To better understand anticancer effects of systemic HCC therapy, we studied sorafenib's effect on macrophage function, focusing on macrophage-related growth factor secretion. We found that dual specificity phosphatase 1 (DUSP1) is a direct target of miR-101. Transfection of miR-101 reduced DUSP1 induction in M2 macrophages and prolonged ERK1/2, p38 and JNK activation, whereas inhibition of miR-101 enhanced DUSP1 expression and decreased ERK1/2, p38 and JNK activation. miR-101 expression was decreased by sorafenib, and inhibition of PI3K/AKT blocked induction of miR-101 by LPS in M2 cells. M2 cells with greater TGF-? and CD206 mRNA expression compared to M1 cells had increased hepatoma growth, metastases and EMT. Sorafenib inhibited miR-101 expression and enhanced DUSP1 expression and lowered TGF-? and CD206 release in M2 cells, slowing macrophage-driven HCC. Our studies demonstrate miR-101 regulates macrophage innate immune responses to LPS via targeting DUSP1. Sorafenib alters macrophage polarization, reduces TGF-? driven cancer growth, metastases and EMT in vitro, and partially inhibits macrophage activation in vivo. Thus, macrophage modulation might explain the anticancer effects of sorafenib. Twit Text FOAVip MiR-101 targets DUSP1 to regulate the TGF- secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26158762 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26158762 #FOAvip English Wikipedia <ref>{{Cite pmid|26158762 }}</ref> MiR-101 targets DUSP1 to regulate the TGF-? secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma #MMPMID26158762 Wei X ; Tang C ; Lu X ; Liu R ; Zhou M ; He D ; Zheng D ; Sun C ; Wu Z Oncotarget 2015[Jul]; 6 (21 ): 18389-405 PMID26158762 show ga Hepatocellular carcinoma (HCC)-associated macrophages accelerate tumor progression via growth factor release. Therefore, tumor-associated macrophages (TAMs)-initiated signaling cascades are potential therapeutic targets. To better understand anticancer effects of systemic HCC therapy, we studied sorafenib's effect on macrophage function, focusing on macrophage-related growth factor secretion. We found that dual specificity phosphatase 1 (DUSP1) is a direct target of miR-101. Transfection of miR-101 reduced DUSP1 induction in M2 macrophages and prolonged ERK1/2, p38 and JNK activation, whereas inhibition of miR-101 enhanced DUSP1 expression and decreased ERK1/2, p38 and JNK activation. miR-101 expression was decreased by sorafenib, and inhibition of PI3K/AKT blocked induction of miR-101 by LPS in M2 cells. M2 cells with greater TGF-? and CD206 mRNA expression compared to M1 cells had increased hepatoma growth, metastases and EMT. Sorafenib inhibited miR-101 expression and enhanced DUSP1 expression and lowered TGF-? and CD206 release in M2 cells, slowing macrophage-driven HCC. Our studies demonstrate miR-101 regulates macrophage innate immune responses to LPS via targeting DUSP1. Sorafenib alters macrophage polarization, reduces TGF-? driven cancer growth, metastases and EMT in vitro, and partially inhibits macrophage activation in vivo. Thus, macrophage modulation might explain the anticancer effects of sorafenib. |Adult [MESH] |Blotting, Western [MESH] |Carcinoma, Hepatocellular/genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects/genetics [MESH] |Cells, Cultured [MESH] |Dual Specificity Phosphatase 1/*genetics/metabolism [MESH] |Enzyme Activation/drug effects [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Lipopolysaccharides/pharmacology [MESH] |Liver Neoplasms/genetics/metabolism/pathology [MESH] |Macrophages/classification/*drug effects/metabolism [MESH] |Male [MESH] |MicroRNAs/*genetics [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |Niacinamide/*analogs & derivatives/pharmacology [MESH] |Phenylurea Compounds/*pharmacology [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Protein Kinase Inhibitors/pharmacology [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Signal Transduction/drug effects [MESH] |Sorafenib [MESH]MiR-101 targets DUSP1 to regulate the TGF-? secretion in sorafenib inh(epmc).pdf DeepDyve Pubget Overpricing