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10.1186/s12891-015-0775-z http://scihub22266oqcxt.onion/10.1186/s12891-015-0775-z C4621876!4621876 !26503103     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26503103 &cmd=llinks): Failed to open stream: HTTP request failed! 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The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review |pdf=|usr=}}{{26503103 }} gab.com Text The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review JO: BMC Musculoskelet Disord http://www.kidney.de/pget.php?&tw=1&pmid=26503103 #FOAvip BACKGROUND: Knee osteoarthritis (OA) is one of the leading causes of disability within the adult population. Current treatment options for OA of the knee include intra-articular (IA) hyaluronic acid (HA), a molecule found intrinsically within the knee joint that provides viscoelastic properties to the synovial fluid. A variety of mechanisms in which HA is thought to combat knee OA are reported in the current basic literature. METHODS: We conducted a comprehensive literature search to identify currently available primary non-clinical basic science articles focussing on the mechanism of action of IA-HA treatment. Included articles were assessed and categorized based on the mechanism of action described within them. The key findings and conclusions from each included article were obtained and analyzed in aggregate with studies of the same categorical assignment. RESULTS: Chondroprotection was the most frequent mechanism reported within the included articles, followed by proteoglycan and glycosaminoglycan synthesis, anti-inflammatory, mechanical, subchondral, and analgesic actions. HA-cluster of differentiation 44 (CD44) receptor binding was the most frequently reported biological cause of the mechanisms presented. High molecular weight HA was seen to be superior to lower molecular weight HA products. HA derived through a biological fermentation process is also described as having favorable safety outcomes over avian-derived HA products. CONCLUSIONS: The non-clinical basic science literature provides evidence for numerous mechanisms in which HA acts on joint structures and function. These actions provide support for the purported clinical benefit of IA-HA in OA of the knee. Future research should not only focus on the pain relief provided by IA-HA treatment, but the disease modification properties that this treatment modality possesses as well. Twit Text FOAVip The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review ????BMC Musculoskelet Disord http://www.kidney.de/pget.php?&tw=1&pmid=26503103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26503103 #FOAvip English Wikipedia <ref>{{Cite pmid|26503103 }}</ref> The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review #MMPMID26503103 Altman RD ; Manjoo A ; Fierlinger A ; Niazi F ; Nicholls M BMC Musculoskelet Disord 2015[Oct]; 16 (ä): 321 PMID26503103 show ga BACKGROUND: Knee osteoarthritis (OA) is one of the leading causes of disability within the adult population. Current treatment options for OA of the knee include intra-articular (IA) hyaluronic acid (HA), a molecule found intrinsically within the knee joint that provides viscoelastic properties to the synovial fluid. A variety of mechanisms in which HA is thought to combat knee OA are reported in the current basic literature. METHODS: We conducted a comprehensive literature search to identify currently available primary non-clinical basic science articles focussing on the mechanism of action of IA-HA treatment. Included articles were assessed and categorized based on the mechanism of action described within them. The key findings and conclusions from each included article were obtained and analyzed in aggregate with studies of the same categorical assignment. RESULTS: Chondroprotection was the most frequent mechanism reported within the included articles, followed by proteoglycan and glycosaminoglycan synthesis, anti-inflammatory, mechanical, subchondral, and analgesic actions. HA-cluster of differentiation 44 (CD44) receptor binding was the most frequently reported biological cause of the mechanisms presented. High molecular weight HA was seen to be superior to lower molecular weight HA products. HA derived through a biological fermentation process is also described as having favorable safety outcomes over avian-derived HA products. CONCLUSIONS: The non-clinical basic science literature provides evidence for numerous mechanisms in which HA acts on joint structures and function. These actions provide support for the purported clinical benefit of IA-HA in OA of the knee. Future research should not only focus on the pain relief provided by IA-HA treatment, but the disease modification properties that this treatment modality possesses as well. |Analgesics/pharmacology/therapeutic use [MESH] |Anti-Inflammatory Agents/pharmacology/therapeutic use [MESH] |Bone and Bones/drug effects [MESH] |Chondrocytes/*drug effects [MESH] |Glycosaminoglycans/biosynthesis [MESH] |Humans [MESH] |Hyaluronic Acid/pharmacology/*therapeutic use [MESH] |Osteoarthritis, Knee/*drug therapy [MESH] |Proteoglycans/biosynthesis [MESH]The mechanism of action for hyaluronic acid treatment in the osteoarth(epmc).pdf DeepDyve Pubget Overpricing