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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Immunol+Rev 2015 ; 268 (1): 66-73 Nephropedia Template TP
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Of ITIMs, ITAMs and ITAMis, revisiting Immunoglobulin Fc Receptor signaling #MMPMID26497513
Getahun A; Cambier JC
Immunol Rev 2015[Nov]; 268 (1): 66-73 PMID26497513show ga
Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system, mediating functions as diverse as phagocytosis, triggering degranulation of basophils and mast cells, promoting immunoglobulin class switching and preventing excessive activation. Transmembrane signaling associated with these functions is mediated primarily by two amino acid sequence motifs, ITAMs (Immunoreceptor Tyrosine-based Activation Motifs) and ITIMs (Immunoreceptor Tyrosine-based Inhibition Motifs) that act as the receptors? interface with activating and inhibitory signaling pathways, respectively. While ITAMs mobilize activating tyrosine kinases and their consorts, ITIMs mobilize opposing tyrosine and inositol-lipid phosphatases. In this review we will discuss our current understanding of signaling by these receptors/motifs and their sometimes blurred lines of function.