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2015 ; 5
(ä): 15635
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Mechanical versus manual chest compressions for out-of-hospital cardiac arrest: a
meta-analysis of randomized controlled trials
#MMPMID26503429
Tang L
; Gu WJ
; Wang F
Sci Rep
2015[Oct]; 5
(ä): 15635
PMID26503429
show ga
Recent evidence regarding mechanical chest compressions in out-of-hospital
cardiac arrest (OHCA) is conflicting. The objective of this study was to perform
a meta-analysis of randomized controlled trials (RCTs) to compare the effect of
mechanical versus manual chest compressions on resuscitation outcomes in OHCA.
PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the
ClinicalTrials.gov registry were searched. In total, five RCTs with 12,510
participants were included. Compared with manual chest compressions, mechanical
chest compressions did not significantly improve survival with good neurological
outcome to hospital discharge (relative risks (RR) 0.80, 95% CI 0.61-1.04,
P?=?0.10; I(2)?=?65%), return of spontaneous circulation (RR 1.02, 95% CI
0.95-1.09, P?=?0.59; I(2)?=?0%), or long-term (?6 months) survival (RR 0.96, 95%
CI 0.79-1.16, P?=?0.65; I(2)?=?16%). In addition, mechanical chest compressions
were associated with worse survival to hospital admission (RR 0.94, 95% CI
0.89-1.00, P?=?0.04; I(2)?=?0%) and to hospital discharge (RR 0.88, 95% CI
0.78-0.99, P?=?0.03; I(2)?=?0%). Based on the current evidence, widespread use of
mechanical devices for chest compressions in OHCA cannot be recommended.