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2015 ; 2015
(ä): 594039
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Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and
Endothelial Dysfunction in Healthy Young Adults
#MMPMID26549941
Cheng C
; Daskalakis C
Mediators Inflamm
2015[]; 2015
(ä): 594039
PMID26549941
show ga
Proinflammatory adipokines (inflammation markers) from visceral adipose tissue
may initiate the development of insulin resistance (IR) and endothelial
dysfunction (ED). This study's objective was to investigate the association of
five inflammation markers (CRP and four adipokines: IL-6, TNF?, PAI-1, and
adiponectin) with IR (quantitative insulin resistance check index (QUICKI)),
microvascular measures (capillary density and albumin-to-creatinine ratio (ACR)),
and endothelial measures (forearm blood flow (FBF) increases from resting
baseline to maximal vasodilation). Analyses were conducted via multiple linear
regression. The 295 study participants were between 18 and 45 years of age,
without diabetes or hypertension. They included 24% African Americans and 21%
Asians with average body mass index of 25.4 kg/m(2). All five inflammation
markers were significantly associated with QUICKI. All but adiponectin were
significantly associated with capillary density, but none were associated with
ACR. Finally, IL-6 and PAI-1 were significantly associated with FBF increase. We
also identified a potential interaction between obesity and IL-6 among
normal-weight and overweight participants: IL-6 appeared to be positively
associated with QUICKI and capillary density (beneficial effect), but the inverse
was true among obese individuals. These study findings suggest that inflammation
measures may be potential early markers of cardiovascular risk in young
asymptomatic individuals.