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10.1371/journal.pone.0141035 http://scihub22266oqcxt.onion/10.1371/journal.pone.0141035 C4621051!4621051!26502079     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (10): ä Nephropedia Template TP {{tp|p=26502079|t=2015. Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study |pdf=|usr=}}{{26502079}} gab.com Text Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26502079 #FOAvip Objectives: Myostatin (MSTN), a member of TGF-? superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR). Subjects and Methods: Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creatinine clearance (ClCr) by the Cockcroft-Gault equation was used as a measure of kidney function. Plasma concentration of MSTN was determined by ELISA. Results: The plasma MSTN level was not different between men (3.42±1.61 ng/mL) and women (3.27±1.43 ng/mL). In a simple regression analysis, the MSTN level was significantly correlated with eGFR (r = -0.25, p<0.01) and ClCr (r = -0.20, p<0.05) but not with age and BMI. In a multiple linear regression analysis, the MSTN level showed a negative correlation with eGFR (standardized ? = -0.31, p<0.01) and ClCr (standardized ? = -0.35, p<0.01) under the adjustment with age, sex, BMI and LDL-C. Weak correlation was observed between the MSTN level and BMI / the serum LDL-C level. When the subjects were stratified into 4 groups according to eGFR, MSTN was significantly greater in the groups with the lowest and the 2nd lowest eGFR (3.55±1.79 and 3.76±1.75 ng/mL, respectively) than the level in the group with the highest eGFR (2.77±0.85 ng/mL). Conclusion: Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia. Twit Text FOAVip Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26502079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26502079 #FOAvip English Wikipedia <ref>{{Cite pmid|26502079}}</ref> Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study #MMPMID26502079 Yano S; Nagai A; Isomura M; Yamasaki M; Kijima T; Takeda M; Hamano T; Nabika T PLoS One 2015[]; 10 (10): ä PMID26502079show ga Objectives: Myostatin (MSTN), a member of TGF-? superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR). Subjects and Methods: Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creatinine clearance (ClCr) by the Cockcroft-Gault equation was used as a measure of kidney function. Plasma concentration of MSTN was determined by ELISA. Results: The plasma MSTN level was not different between men (3.42±1.61 ng/mL) and women (3.27±1.43 ng/mL). In a simple regression analysis, the MSTN level was significantly correlated with eGFR (r = -0.25, p<0.01) and ClCr (r = -0.20, p<0.05) but not with age and BMI. In a multiple linear regression analysis, the MSTN level showed a negative correlation with eGFR (standardized ? = -0.31, p<0.01) and ClCr (standardized ? = -0.35, p<0.01) under the adjustment with age, sex, BMI and LDL-C. Weak correlation was observed between the MSTN level and BMI / the serum LDL-C level. When the subjects were stratified into 4 groups according to eGFR, MSTN was significantly greater in the groups with the lowest and the 2nd lowest eGFR (3.55±1.79 and 3.76±1.75 ng/mL, respectively) than the level in the group with the highest eGFR (2.77±0.85 ng/mL). Conclusion: Plasma MSTN level was elevated in an early stage of CKD, which could be involved in the progression of sarcopenia. äRelationship between Blood Myostatin Levels and Kidney Function:Shiman(epmc).pdf DeepDyve Pubget Overpricing