Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26501139
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2015 ; 10
(10
): e0141168
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and
Forms a Positive Feedback Loop with ?-catenin/c-Jun Signaling Pathway in
Extra-Hepatic Cholangiocarcinoma
#MMPMID26501139
Li J
; Yao L
; Li G
; Ma D
; Sun C
; Gao S
; Zhang P
; Gao F
PLoS One
2015[]; 10
(10
): e0141168
PMID26501139
show ga
Extrahepatic cholangiocarcinoma (EHCC) is a refractory malignancy with poor
prognosis due to its early invasion, metastasis and recurrence after operation.
Therefore, understanding the mechanisms of invasion and metastasis is the key to
the development of new and effective therapeutic strategies for EHCC. In the
present study we demonstrated that miR-221 promoted EHCC invasion and metastasis
through targeting PTEN and formed a positive feedback loop with ?-catenin/c-Jun
signaling pathway. We found miR-221 was upregulated in EHCC specimens and CC cell
lines. Moreover, miR-221 was found strongly associated with the metastasis and
prognosis of EHCC patients. The expression of PTEN was downregulated in EHCC
patients and CC cell lines, and was further demonstrated as one of the downstream
targets of miR-221. In addition, our data indicated that ?-catenin activated
miR-221 through c-jun, while miR-221 enhanced ?-catenin signaling
induced-epithelial-mesenchymal transition (EMT) by targeting PTEN, hence forming
a positive feedback loop in EHCC cell lines. In conclusion, our results suggested
that miR-221 promotes EMT through targeting PTEN and forms a positive feedback
loop with ?-catenin/c-Jun signaling pathway in EHCC.