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10.1073/pnas.1420404112 http://scihub22266oqcxt.onion/10.1073/pnas.1420404112 C4620908!4620908!26438844     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (42): 13115-20 Nephropedia Template TP {{tp|p=26438844|t=2015. Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |pdf=|usr=}}{{26438844}} gab.com Text Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26438844 #FOAvip Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing delays are more common for short genes, which would otherwise be expected to transcribe most rapidly. The distribution of intronic reads suggests that these delays are required for splicing to be completed. Understanding such delays is essential for understanding how a rapid cellular response is regulated. Twit Text FOAVip Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26438844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26438844 #FOAvip English Wikipedia <ref>{{Cite pmid|26438844}}</ref> Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays #MMPMID26438844 Honkela A; Peltonen J; Topa H; Charapitsa I; Matarese F; Grote K; Stunnenberg HG; Reid G; Lawrence ND; Rattray M Proc Natl Acad Sci U S A 2015[Oct]; 112 (42): 13115-20 PMID26438844show ga Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing delays are more common for short genes, which would otherwise be expected to transcribe most rapidly. The distribution of intronic reads suggests that these delays are required for splicing to be completed. Understanding such delays is essential for understanding how a rapid cellular response is regulated. äGenome-wide modeling of transcription kinetics reveals patterns of RNA(epmc).pdf DeepDyve Pubget Overpricing