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10.1038/srep15282 http://scihub22266oqcxt.onion/10.1038/srep15282 C4620496!4620496 !26497260     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26497260 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo |pdf=|usr=}}{{26497260 }} gab.com Text Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26497260 #FOAvip Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1? and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes in human macrophages. However, whether HSM may be used to prevent lung fibrosis and the mechanism underlying this activity remain unclear. Our results show that pretreatment with HSM inhibits TGF-?1-induced expression of fibronectin and ?-SMA in lung fibroblasts. HSM also restores superoxide dismutase expression in TGF-?1-treated lung fibroblasts and inhibits reactive oxygen species production in lung epithelial cells. Furthermore, HSM pretreatment markedly reduces bleomycin-induced lung injury and fibrosis in mice. Accordingly, HSM reduces inflammatory cell accumulation in bronchoalveolar lavage fluid and proinflammatory cytokines levels in lung tissues. The HSM extract also significantly reduces TGF-?1 in lung tissues, and this effect is accompanied by decreased collagen 3?1 and ?-SMA levels. Moreover, HSM reduces expression of the NLRP3 inflammasome and P2X7R in lung tissues, whereas it enhances expression of superoxide dismutase. These findings suggest that HSM may be used for the treatment of pulmonary inflammation and fibrosis. Twit Text FOAVip Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26497260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26497260 #FOAvip English Wikipedia <ref>{{Cite pmid|26497260 }}</ref> Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo #MMPMID26497260 Huang TT ; Lai HC ; Ko YF ; Ojcius DM ; Lan YW ; Martel J ; Young JD ; Chong KY Sci Rep 2015[Oct]; 5 (ä): 15282 PMID26497260 show ga Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1? and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes in human macrophages. However, whether HSM may be used to prevent lung fibrosis and the mechanism underlying this activity remain unclear. Our results show that pretreatment with HSM inhibits TGF-?1-induced expression of fibronectin and ?-SMA in lung fibroblasts. HSM also restores superoxide dismutase expression in TGF-?1-treated lung fibroblasts and inhibits reactive oxygen species production in lung epithelial cells. Furthermore, HSM pretreatment markedly reduces bleomycin-induced lung injury and fibrosis in mice. Accordingly, HSM reduces inflammatory cell accumulation in bronchoalveolar lavage fluid and proinflammatory cytokines levels in lung tissues. The HSM extract also significantly reduces TGF-?1 in lung tissues, and this effect is accompanied by decreased collagen 3?1 and ?-SMA levels. Moreover, HSM reduces expression of the NLRP3 inflammasome and P2X7R in lung tissues, whereas it enhances expression of superoxide dismutase. These findings suggest that HSM may be used for the treatment of pulmonary inflammation and fibrosis. |Animals [MESH] |Ascomycota/*physiology [MESH] |Bleomycin/*toxicity [MESH] |Humans [MESH] |Mice [MESH] |Mycelium/*physiology [MESH] |Pneumonia/*chemically induced [MESH] |Pulmonary Fibrosis/*chemically induced [MESH]Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary in(epmc).pdf DeepDyve Pubget Overpricing