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2015 ; 2015
(ä): 485839
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The Effects of Simvastatin on Proteinuria and Renal Function in Patients with
Chronic Kidney Disease
#MMPMID26543646
Satirapoj B
; Promrattanakun A
; Supasyndh O
; Choovichian P
Int J Nephrol
2015[]; 2015
(ä): 485839
PMID26543646
show ga
Current data suggests that statins might have beneficial effects on renal
outcomes. Beneficial effects of statin treatment on renal progression in advanced
chronic kidney disease (CKD) are obviously controversial. In a retrospective,
controlled study, the authors have evaluated the effects of 53-week treatment
with simvastatin, versus no treatment on proteinuria and renal function among 51
patients with CKD stages III-IV. By the end of the 53-week treatment, urine
protein excretion decreased from 0.96 (IQR 0.54, 2.9) to 0.48 (IQR 0.18,
0.79)?g/g creatinine (P < 0.001) in patients treated with simvastatin in addition
to ACEI and ARBs, while no change was observed among the untreated patients.
Moreover, a significantly greater decrease in urine protein excretion was
observed in the simvastatin group as compared with the untreated group. The mean
changes of serum creatinine and eGFR did not significantly differ in both groups.
A significantly greater decrease in total cholesterol and LDL-cholesterol was
found in the simvastatin group than in the untreated group. In summary, apart
from lipid lowering among CKD patients, ingesting simvastatin was associated with
a decrease in proteinuria. These statin effects may become important for
supportive therapy in renal damage in the future.