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http://scihub22266oqcxt.onion/ C4620183!4620183 !26523217     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26523217 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Iran+J+Basic+Med+Sci 2015 ; 18 (9 ): 856-61 Nephropedia Template TP {{tp|p=26523217 |t=2015. Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-? receptor I kinase inhibitor (SD-208) |pdf=|usr=}}{{26523217 }} gab.com Text Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF- receptor I kinase inhibitor (SD-208) JO: Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26523217 #FOAvip OBJECTIVES: Transforming growth factor-? (TGF-?) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-? signaling. This work aims to show the effect of manipulation of TGF-? signaling on some miRNAs implicated in CRC. MATERIALS AND METHODS: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 ?M concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b) and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c). Data were analyzed using the 2-??CT method through student's t-test via the GraphPad Prism software. RESULTS: Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006) or tumors orthotopically implanted in nude mice (P=0.018). Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. CONCLUSION: Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-? inhibitors) may be owing to their ability to regulate miRNAs expression. Twit Text FOAVip Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF- receptor I kinase inhibitor (SD-208) ????Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26523217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26523217 #FOAvip English Wikipedia <ref>{{Cite pmid|26523217 }}</ref> Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-? receptor I kinase inhibitor (SD-208) #MMPMID26523217 Akbari A ; Ghahremani MH ; Mobini GR ; Abastabar M ; Akhtari J ; Bolhassani M ; Heidari M Iran J Basic Med Sci 2015[Sep]; 18 (9 ): 856-61 PMID26523217 show ga OBJECTIVES: Transforming growth factor-? (TGF-?) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-? signaling. This work aims to show the effect of manipulation of TGF-? signaling on some miRNAs implicated in CRC. MATERIALS AND METHODS: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 ?M concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b) and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c). Data were analyzed using the 2-??CT method through student's t-test via the GraphPad Prism software. RESULTS: Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006) or tumors orthotopically implanted in nude mice (P=0.018). Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. CONCLUSION: Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-? inhibitors) may be owing to their ability to regulate miRNAs expression. äDown-regulation of miR-135b in colon adenocarcinoma induced by a TGF-?(epmc).pdf DeepDyve Pubget Overpricing