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10.1186/s12885-015-1783-y http://scihub22266oqcxt.onion/10.1186/s12885-015-1783-y C4619995!4619995!26499327     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Cancer 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26499327|t=2015. Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer |pdf=|usr=}}{{26499327}} gab.com Text Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26499327 #FOAvip Background: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Methods: The expression profiles of cancer cells in 152 patients with stage I-III CRC were examined using microarray analysis. High expression in CRC cells, especially in patients with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways. We analyzed the protein expression of TNIK using immunohistochemistry (IHC) and investigated the relationship between protein expression and patient characteristics in 220 stage I-III CRC patients. Results: Relapse-free survival was significantly worse in the TNIK high expression group than in the TNIK low expression group in stage II (p?=?0.028) and stage III (p?=?0.006) patients. In multivariate analysis, high TNIK expression was identified as a significant independent risk factor of distant recurrence in stage III patients. Conclusion: This study is the first to demonstrate the prognostic significance of intratumoral TNIK protein expression in clinical tissue samples of CRC, in that high expression of TNIK protein in primary tumors was associated with distant recurrence in stage II and III CRC patients. This TNIK IHC study might contribute to practical decision-making in the treatment of these patients. Electronic supplementary material: The online version of this article (doi:10.1186/s12885-015-1783-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26499327 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26499327 #FOAvip English Wikipedia <ref>{{Cite pmid|26499327}}</ref> Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer #MMPMID26499327 Takahashi H; Ishikawa T; Ishiguro M; Okazaki S; Mogushi K; Kobayashi H; Iida S; Mizushima H; Tanaka H; Uetake H; Sugihara K BMC Cancer 2015[]; 15 (ä): ä PMID26499327show ga Background: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Methods: The expression profiles of cancer cells in 152 patients with stage I-III CRC were examined using microarray analysis. High expression in CRC cells, especially in patients with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected Traf2- and Nck-interacting kinase (TNIK), which was known to be associated with progression in CRC through Wnt signaling pathways. We analyzed the protein expression of TNIK using immunohistochemistry (IHC) and investigated the relationship between protein expression and patient characteristics in 220 stage I-III CRC patients. Results: Relapse-free survival was significantly worse in the TNIK high expression group than in the TNIK low expression group in stage II (p?=?0.028) and stage III (p?=?0.006) patients. In multivariate analysis, high TNIK expression was identified as a significant independent risk factor of distant recurrence in stage III patients. Conclusion: This study is the first to demonstrate the prognostic significance of intratumoral TNIK protein expression in clinical tissue samples of CRC, in that high expression of TNIK protein in primary tumors was associated with distant recurrence in stage II and III CRC patients. This TNIK IHC study might contribute to practical decision-making in the treatment of these patients. Electronic supplementary material: The online version of this article (doi:10.1186/s12885-015-1783-y) contains supplementary material, which is available to authorized users. äPrognostic significance of Traf2- and Nck- interacting kinase (TNIK) i(epmc).pdf DeepDyve Pubget Overpricing