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10.1155/2015/630932

http://scihub22266oqcxt.onion/10.1155/2015/630932
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suck abstract from ncbi


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pmid26568892
      Neural+Plast 2015 ; 2015 (ä): 630932
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  • Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury #MMPMID26568892
  • Shin JC ; Kim KN ; Yoo J ; Kim IS ; Yun S ; Lee H ; Jung K ; Hwang K ; Kim M ; Lee IS ; Shin JE ; Park KI
  • Neural Plast 2015[]; 2015 (ä): 630932 PMID26568892 show ga
  • In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A ? C), 1 (A ? B), and 2 (B ? D), whereas only one patient in the control group showed improvement (A ? B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Cervical Cord/*injuries [MESH]
  • |Female [MESH]
  • |Fetal Stem Cells/*transplantation [MESH]
  • |Humans [MESH]
  • |Lower Extremity/innervation/physiopathology [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Motor Activity [MESH]
  • |Muscle Spasticity [MESH]
  • |Neural Conduction [MESH]
  • |Neural Stem Cells/*transplantation [MESH]
  • |Pain Measurement [MESH]
  • |Spinal Cord Injuries/pathology/*rehabilitation/*therapy [MESH]
  • |Stem Cell Transplantation/*adverse effects [MESH]
  • |Treatment Outcome [MESH]
  • |Upper Extremity/innervation/physiopathology [MESH]


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