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2015 ; 2015
(ä): 630932
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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell
Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
#MMPMID26568892
Shin JC
; Kim KN
; Yoo J
; Kim IS
; Yun S
; Lee H
; Jung K
; Hwang K
; Kim M
; Lee IS
; Shin JE
; Park KI
Neural Plast
2015[]; 2015
(ä): 630932
PMID26568892
show ga
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we
sought to assess the safety and neurological effects of human neural
stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic
cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor
complete and 2 were motor complete and sensory incomplete. hNSPCs derived from
the fetal telencephalon were grown as neurospheres and transplanted into the
cord. In the control group, who did not receive cell implantation but were
otherwise closely matched with the transplantation group, 15 patients with
traumatic cervical SCI were included. At 1 year after cell transplantation, there
was no evidence of cord damage, syrinx or tumor formation, neurological
deterioration, and exacerbating neuropathic pain or spasticity. The American
Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19
transplanted patients, 2 (A ? C), 1 (A ? B), and 2 (B ? D), whereas only one
patient in the control group showed improvement (A ? B). Improvements included
increased motor scores, recovery of motor levels, and responses to
electrophysiological studies in the transplantation group. Therefore, the
transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of
modest neurological benefit up to 1 year after transplants. This trial is
registered with Clinical Research Information Service (CRIS), Registration
Number: KCT0000879.