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10.1186/s12910-015-0066-0

http://scihub22266oqcxt.onion/10.1186/s12910-015-0066-0
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C4619576!4619576!26498961
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suck abstract from ncbi


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pmid26498961      BMC+Med+Ethics 2015 ; 16 (ä): ä
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  • Key factors in children?s competence to consent to clinical research #MMPMID26498961
  • Hein IM; Troost PW; Lindeboom R; Benninga MA; Zwaan CM; van Goudoever JB; Lindauer RJ
  • BMC Med Ethics 2015[]; 16 (ä): ä PMID26498961show ga
  • Background: Although law is established on a strong presumption that persons younger than a certain age are not competent to consent, statutory age limits for asking children?s consent to clinical research differ widely internationally. From a clinical perspective, competence is assumed to involve many factors including the developmental stage, the influence of parents and peers, and life experience. We examined potential determining factors for children?s competence to consent to clinical research and to what extent they explain the variation in competence judgments. Methods: From January 1, 2012 through January 1, 2014, pediatric patients aged 6 to 18 years, eligible for clinical research studies were enrolled prospectively at various in- and outpatient pediatric departments. Children?s competence to consent was assessed by MacArthur Competence Assessment Tool for Clinical Research. Potential determining child variables included age, gender, intelligence, disease experience, ethnicity and socio-economic status (SES). We used logistic regression analysis and change in explained variance in competence judgments to quantify the contribution of a child variable to the total explained variance. Contextual factors included risk and complexity of the decision to participate, parental competence judgment and the child?s or parents decision to participate. Results: Out of 209 eligible patients, 161 were included (mean age, 10.6 years, 47.2 % male). Age, SES, intelligence, ethnicity, complexity, parental competence judgment and trial participation were univariately associated with competence (P??0.05). Conclusions: Age is the factor that explaines most of to the variance in children?s competence to consent, followed by intelligence. Experience with disease did not affect competence in this study, nor did other variables. Clinical trial registration: Development and use of a standardized instrument for assessing children?s competence to consent in drug trials: Are legally established age limits valid?, NTR3918.
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