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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Musculoskelet+Disord 2015 ; 16 (ä): ä Nephropedia Template TP
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Profiles of responses of immunological factors to different subtypes of Kawasaki disease #MMPMID26497060
Ding Y; Li G; Xiong LJ; Yin W; Liu J; Liu F; Wang RG; Xia K; Zhang SL; Zhao L
BMC Musculoskelet Disord 2015[]; 16 (ä): ä PMID26497060show ga
Background: The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood. Methods: We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry. The levels of serum IgG, IgM, IgA and C3, C4 were assessed via velocity scatter turbidimetry. Results: The most significant differences noted between the patients with infectious febrile disease and the normal children were the elevated levels of B cells, C3 and the ratio of CD4/CD8, and the decreased levels of CD8+ T cells and NK cells, as well as the moderate increase in the absolute value of the CD3+ cells. The decreased T cell levels and the elevated B cell levels were helpful in distinguishing typical KD from atypical KD; the elevated T cell levels, the elevated NK cell and B cell levels and the decreased B cell levels were helpful in predicting the effectiveness of IVIG; low C3 and C4 levels were linked with prodromal infections. Conclusions: Lymphocytes subsets and complement markers may be useful in differentiating among the different subtypes of KD and in helping clinicians understand the pathophysiology of KD.