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10.1016/j.stemcr.2015.07.013 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.07.013 C4618596!4618596 !26321145     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26321145 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses |pdf=|usr=}}{{26321145 }} gab.com Text Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26321145 #FOAvip Multipotent human mesenchymal stromal cells (hMSCs) harbor immunomodulatory properties that are therapeutically relevant. One of the most clinically important populations of leukocytes is the interleukin-17A (IL-17A)-secreting T (Th17) lymphocytes. However, mechanisms of hMSC and Th17 cell interactions are incompletely resolved. We found that, along with Th1 responses, hMSCs strongly suppressed Th17 responses and this required both IL-25--also known as IL--17E-as well as programmed death ligand-1 (PD-L1), a potent cell surface ligand for tolerance induction. Knockdown of IL-25 expression in hMSCs abrogated Th17 suppression in vitro and in vivo. However, IL-25 alone was insufficient to significantly suppress Th17 responses, which also required surface PD-L1 expression. Critically, IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter. Our findings demonstrate the complexities of hMSC-mediated Th17 suppression, and highlight the IL-25/STAT3/PD-L1 axis as a candidate therapeutic target. Twit Text FOAVip Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26321145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26321145 #FOAvip English Wikipedia <ref>{{Cite pmid|26321145 }}</ref> Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses #MMPMID26321145 Wang WB ; Yen ML ; Liu KJ ; Hsu PJ ; Lin MH ; Chen PM ; Sudhir PR ; Chen CH ; Chen CH ; Sytwu HK ; Yen BL Stem Cell Reports 2015[Sep]; 5 (3 ): 392-404 PMID26321145 show ga Multipotent human mesenchymal stromal cells (hMSCs) harbor immunomodulatory properties that are therapeutically relevant. One of the most clinically important populations of leukocytes is the interleukin-17A (IL-17A)-secreting T (Th17) lymphocytes. However, mechanisms of hMSC and Th17 cell interactions are incompletely resolved. We found that, along with Th1 responses, hMSCs strongly suppressed Th17 responses and this required both IL-25--also known as IL--17E-as well as programmed death ligand-1 (PD-L1), a potent cell surface ligand for tolerance induction. Knockdown of IL-25 expression in hMSCs abrogated Th17 suppression in vitro and in vivo. However, IL-25 alone was insufficient to significantly suppress Th17 responses, which also required surface PD-L1 expression. Critically, IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter. Our findings demonstrate the complexities of hMSC-mediated Th17 suppression, and highlight the IL-25/STAT3/PD-L1 axis as a candidate therapeutic target. |B7-H1 Antigen/genetics/*immunology [MESH] |Gene Expression Regulation/immunology [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Interleukin-17/*immunology [MESH] |Mesenchymal Stem Cells/cytology/*immunology [MESH] |STAT3 Transcription Factor/genetics/*immunology [MESH] |Th17 Cells/cytology/*immunology [MESH]Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in (epmc).pdf DeepDyve Pubget Overpricing