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10.1001/archophthalmol.2009.311 http://scihub22266oqcxt.onion/10.1001/archophthalmol.2009.311 C4618318!4618318!20008709     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Ophthalmol 2009 ; 127 (12): 1572-80 Nephropedia Template TP {{tp|p=20008709|t=2009. Melanoma-Associated Retinopathy: A Paraneoplastic Autoimmune Complication |pdf=|usr=}}{{20008709}} gab.com Text Melanoma-Associated Retinopathy: A Paraneoplastic Autoimmune Complication JO: Arch Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=20008709 #FOAvip Objectives: To study 11 patients with melanoma-associated retinopathy (MAR) to clarify the reliability of various methods of diagnostic testing, to determine the underlying antigenic retinal proteins, and to study the clinical histories and types of associated melanomas. Methods: Clinical data were obtained from patients with melanoma who developed marked visual problems. Testing included electroretinography, kinetic visual fields, comparative studies of Western blots, and indirect immunohistologic examination to detect antiretinal antibodies, as well as proteomic studies to identify underlying antigenic retinal proteins. Results: Patients with MAR typically have rapid onset of photopsias, scotomata, and loss of central or paracentral vision. Ophthalmoscopy seldom shows significant changes early, but electroretinograms are abnormal. Results of Western blots and immunohistologic examination can show antiretinal antibodies but not always. Most patients (9 of 11) had a strong family history of autoimmune disorders. Any type of melanoma (cutaneous, choroidal, ciliary body, or choroidal nevi) may be associated with this paraneoplastic autoimmune reactivity. MAR may precede or follow the diagnosis of melanoma. Patients with MAR have the same antigenic retinal proteins that have been associated with cancer-associated retinopathy. In addition, 2 new antigenic retinal proteins, aldolase A and aldolase C, were found. Conclusions: There was a high prevalence of positive family histories of autoimmune disease in patients with MAR. To confirm the disorder, multiple clinical and serum diagnostic techniques (Western blot or indirect immunohistologic examination) are needed. Two newly observed antigenic retinal proteins, aldolase A and aldolase C, are associated with MAR. Twit Text FOAVip Melanoma-Associated Retinopathy: A Paraneoplastic Autoimmune Complication ????Arch Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=20008709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20008709 #FOAvip English Wikipedia <ref>{{Cite pmid|20008709}}</ref> Melanoma-Associated Retinopathy: A Paraneoplastic Autoimmune Complication #MMPMID20008709 Lu Y; Jia L; He S; Hurley MC; Leys MJ; Jayasundera T; Heckenlively JR Arch Ophthalmol 2009[Dec]; 127 (12): 1572-80 PMID20008709show ga Objectives: To study 11 patients with melanoma-associated retinopathy (MAR) to clarify the reliability of various methods of diagnostic testing, to determine the underlying antigenic retinal proteins, and to study the clinical histories and types of associated melanomas. Methods: Clinical data were obtained from patients with melanoma who developed marked visual problems. Testing included electroretinography, kinetic visual fields, comparative studies of Western blots, and indirect immunohistologic examination to detect antiretinal antibodies, as well as proteomic studies to identify underlying antigenic retinal proteins. Results: Patients with MAR typically have rapid onset of photopsias, scotomata, and loss of central or paracentral vision. Ophthalmoscopy seldom shows significant changes early, but electroretinograms are abnormal. Results of Western blots and immunohistologic examination can show antiretinal antibodies but not always. Most patients (9 of 11) had a strong family history of autoimmune disorders. Any type of melanoma (cutaneous, choroidal, ciliary body, or choroidal nevi) may be associated with this paraneoplastic autoimmune reactivity. MAR may precede or follow the diagnosis of melanoma. Patients with MAR have the same antigenic retinal proteins that have been associated with cancer-associated retinopathy. In addition, 2 new antigenic retinal proteins, aldolase A and aldolase C, were found. Conclusions: There was a high prevalence of positive family histories of autoimmune disease in patients with MAR. To confirm the disorder, multiple clinical and serum diagnostic techniques (Western blot or indirect immunohistologic examination) are needed. Two newly observed antigenic retinal proteins, aldolase A and aldolase C, are associated with MAR. äMelanoma-Associated Retinopathy: A Paraneoplastic Autoimmune Complicat(epmc).pdf DeepDyve Pubget Overpricing