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10.1016/j.celrep.2015.09.014 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.09.014 C4618173!4618173!26456820     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 13 (3): 524-32 Nephropedia Template TP {{tp|p=26456820|t=2015. Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins |pdf=|usr=}}{{26456820}} gab.com Text Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26456820 #FOAvip As the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited. Here, we find that tankyrase inhibitors suppress YAP activity. This effect is mediated by anigomotin (AMOT) family proteins. Tankyrases associate with AMOT family proteins and promote their degradation through E3 ligase RNF146. By antagonizing tankyrase activity, tankyrase inhibitors stabilize AMOT family proteins, thereby suppressing YAP oncogenic functions. Together, our studies not only demonstrate the tankyrase-RNF146-AMOT axis as an upstream pathway regulating YAP, but also reveal a therapeutic opportunity in targeting YAP for cancer treatment. Twit Text FOAVip Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26456820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26456820 #FOAvip English Wikipedia <ref>{{Cite pmid|26456820}}</ref> Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins #MMPMID26456820 Wang W; Li N; Li X; Tran MK; Han X; Chen J Cell Rep 2015[Oct]; 13 (3): 524-32 PMID26456820show ga As the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited. Here, we find that tankyrase inhibitors suppress YAP activity. This effect is mediated by anigomotin (AMOT) family proteins. Tankyrases associate with AMOT family proteins and promote their degradation through E3 ligase RNF146. By antagonizing tankyrase activity, tankyrase inhibitors stabilize AMOT family proteins, thereby suppressing YAP oncogenic functions. Together, our studies not only demonstrate the tankyrase-RNF146-AMOT axis as an upstream pathway regulating YAP, but also reveal a therapeutic opportunity in targeting YAP for cancer treatment. äTankyrase inhibitors target YAP by stabilizing angiomotin family prote(epmc).pdf DeepDyve Pubget Overpricing