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10.1371/journal.ppat.1005209 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005209 C4618121!4618121 !26485648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26485648 &cmd=llinks): Failed to open stream: HTTP request failed! 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Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia |pdf=|usr=}}{{26485648 }} gab.com Text Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26485648 #FOAvip Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury over years of chronic infection. We show that O. viverrini secreted proteins accelerated wound resolution in human cholangiocytes, an outcome that was compromised following silencing of expression of the fluke-derived gene encoding the granulin-like growth factor, Ov-GRN-1. Recombinant Ov-GRN-1 induced angiogenesis and accelerated mouse wound healing. Ov-GRN-1 was internalized by human cholangiocytes and induced gene and protein expression changes associated with wound healing and cancer pathways. Given the notable but seemingly paradoxical properties of liver fluke granulin in promoting not only wound healing but also a carcinogenic microenvironment, Ov-GRN-1 likely holds marked potential as a therapeutic wound-healing agent and as a vaccine against an infection-induced cancer of major public health significance in the developing world. Twit Text FOAVip Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26485648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26485648 #FOAvip English Wikipedia <ref>{{Cite pmid|26485648 }}</ref> Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia #MMPMID26485648 Smout MJ ; Sotillo J ; Laha T ; Papatpremsiri A ; Rinaldi G ; Pimenta RN ; Chan LY ; Johnson MS ; Turnbull L ; Whitchurch CB ; Giacomin PR ; Moran CS ; Golledge J ; Daly N ; Sripa B ; Mulvenna JP ; Brindley PJ ; Loukas A PLoS Pathog 2015[Oct]; 11 (10 ): e1005209 PMID26485648 show ga Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury over years of chronic infection. We show that O. viverrini secreted proteins accelerated wound resolution in human cholangiocytes, an outcome that was compromised following silencing of expression of the fluke-derived gene encoding the granulin-like growth factor, Ov-GRN-1. Recombinant Ov-GRN-1 induced angiogenesis and accelerated mouse wound healing. Ov-GRN-1 was internalized by human cholangiocytes and induced gene and protein expression changes associated with wound healing and cancer pathways. Given the notable but seemingly paradoxical properties of liver fluke granulin in promoting not only wound healing but also a carcinogenic microenvironment, Ov-GRN-1 likely holds marked potential as a therapeutic wound-healing agent and as a vaccine against an infection-induced cancer of major public health significance in the developing world. |Amino Acid Sequence [MESH] |Animals [MESH] |Bile Duct Neoplasms/parasitology [MESH] |Carcinogenesis/*metabolism [MESH] |Cholangiocarcinoma/parasitology [MESH] |Helminth Proteins/*metabolism [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/*metabolism [MESH] |Mice [MESH] |Microscopy, Confocal [MESH] |Molecular Sequence Data [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Opisthorchiasis/*complications/metabolism [MESH] |Opisthorchis/*metabolism [MESH] |Progranulins [MESH] |RNA Interference [MESH]Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound He(epmc).pdf DeepDyve Pubget Overpricing