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2015 ; 2015
(ä): 415984
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Alteration of Blood Parameters and Histoarchitecture of Liver and Kidney of
Silver Barb after Chronic Exposure to Quinalphos
#MMPMID26635877
Mohammod Mostakim G
; Zahangir MM
; Monir Mishu M
; Rahman MK
; Islam MS
J Toxicol
2015[]; 2015
(ä): 415984
PMID26635877
show ga
Quinalphos (QP) is commonly used for pest control in the agricultural fields
surrounding freshwater reservoirs. This study was conducted to evaluate the
chronic toxicity of this pesticide on blood parameters and some organs of silver
barb, Barbonymus gonionotus. Fish were exposed to two sublethal concentrations,
0.47?ppm and 0.94?ppm, of QP for a period of 28 days. All the blood parameters
(red blood cell, hematocrit, and hemoglobin) and blood glucose except for white
blood cells decreased with increasing concentration of toxicant and become
significantly lower (p < 0.05) at higher concentration when compared with
control. The derived hematological indices of mean corpuscular volume, mean
corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were
equally altered compared to control. Histoarchitectural changes of liver and
kidney were observed after exposure to the QP. Hypertrophy of hepatocytes, mild
to severe necrosis, ruptured central vein, and vacuolation were observed in the
liver of treated groups. Highly degenerated kidney tubules and hematopoietic
tissue, degeneration of renal corpuscle, vacuolization, and necrosis were evident
in the kidney of treated groups. In conclusion, chronic exposure to QP at
sublethal concentrations induced hematological and histological alterations in
silver barb and offers a simple tool to evaluate toxicity derived alterations.