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10.1002/stem.2096 http://scihub22266oqcxt.onion/10.1002/stem.2096 C4618081!4618081!26220362     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cells 2015 ; 33 (11): 3356-67 Nephropedia Template TP {{tp|p=26220362|t=2015. Wnt/?-catenin-Responsive Cells in Prostatic Development and Regeneration |pdf=|usr=}}{{26220362}} gab.com Text Wnt/ -catenin-Responsive Cells in Prostatic Development and Regeneration JO: Stem Cells http://www.kidney.de/pget.php?&tw=1&pmid=26220362 #FOAvip The precise role of Wnt/?-catenin signaling during prostatic development and tumorigenesis is unclear. Axin2 is a direct transcriptional target of ?-catenin. Recent studies have shown that Axin2-expressing cells have stem/progenitor cell properties in a variety of mouse tissues. Here, we genetically labeled Axin2-expressing cells at various time points and tracked their cellular behavior at different developmental and mature stages. We found that prostatic Axin2-expressing cells mainly express luminal epithelial cell markers and are able to expand luminal cell lineages during prostatic development and maturation. They can also survive androgen withdrawal and regenerate prostatic luminal epithelial cells following androgen replacement. Deletion of ?-catenin or expression of stabilized ?-catenin in these Axin2-expressing cells results in abnormal development and oncogenic transformation, respectively. Our study uncovers a critical role of Wnt/?-catenin-responsive cells in prostatic development and regeneration, and that dysregulation of Wnt/?-catenin signaling in these cells contributes to prostatic developmental defects and tumorigenesis. Twit Text FOAVip Wnt/ -catenin-Responsive Cells in Prostatic Development and Regeneration ????Stem Cells http://www.kidney.de/pget.php?&tw=1&pmid=26220362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26220362 #FOAvip English Wikipedia <ref>{{Cite pmid|26220362}}</ref> Wnt/?-catenin-Responsive Cells in Prostatic Development and Regeneration #MMPMID26220362 Lee SH; Johnson DT; Luong R; Yu EJ; Cunha GR; Nusse R; Sun Z Stem Cells 2015[Nov]; 33 (11): 3356-67 PMID26220362show ga The precise role of Wnt/?-catenin signaling during prostatic development and tumorigenesis is unclear. Axin2 is a direct transcriptional target of ?-catenin. Recent studies have shown that Axin2-expressing cells have stem/progenitor cell properties in a variety of mouse tissues. Here, we genetically labeled Axin2-expressing cells at various time points and tracked their cellular behavior at different developmental and mature stages. We found that prostatic Axin2-expressing cells mainly express luminal epithelial cell markers and are able to expand luminal cell lineages during prostatic development and maturation. They can also survive androgen withdrawal and regenerate prostatic luminal epithelial cells following androgen replacement. Deletion of ?-catenin or expression of stabilized ?-catenin in these Axin2-expressing cells results in abnormal development and oncogenic transformation, respectively. Our study uncovers a critical role of Wnt/?-catenin-responsive cells in prostatic development and regeneration, and that dysregulation of Wnt/?-catenin signaling in these cells contributes to prostatic developmental defects and tumorigenesis. äWnt/?-catenin-Responsive Cells in Prostatic Development and Regenerati(epmc).pdf DeepDyve Pubget Overpricing