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10.1101/gr.190314.115 http://scihub22266oqcxt.onion/10.1101/gr.190314.115 C4617961!4617961 !26232412     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26232412 &cmd=llinks): Failed to open stream: HTTP request failed! 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Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor |pdf=|usr=}}{{26232412 }} gab.com Text Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26232412 #FOAvip Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome sequences, thereby separating alleles derived from the founder's genome from somatic mutations that must drive clonal transmissibility. We show that CTVT has undergone continuous adaptation to its transmissible allograft niche, with overlapping mutations at every step of immunosurveillance, particularly self-antigen presentation and apoptosis. We also identified chronologically early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators of clonal transmissibility. Thus, we provide the first insights into the specific genomic aberrations that underlie CTVT's dogged perseverance in canids around the world. Twit Text FOAVip Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26232412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26232412 #FOAvip English Wikipedia <ref>{{Cite pmid|26232412 }}</ref> Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor #MMPMID26232412 Decker B ; Davis BW ; Rimbault M ; Long AH ; Karlins E ; Jagannathan V ; Reiman R ; Parker HG ; Drögemüller C ; Corneveaux JJ ; Chapman ES ; Trent JM ; Leeb T ; Huentelman MJ ; Wayne RK ; Karyadi DM ; Ostrander EA Genome Res 2015[Nov]; 25 (11 ): 1646-55 PMID26232412 show ga Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome sequences, thereby separating alleles derived from the founder's genome from somatic mutations that must drive clonal transmissibility. We show that CTVT has undergone continuous adaptation to its transmissible allograft niche, with overlapping mutations at every step of immunosurveillance, particularly self-antigen presentation and apoptosis. We also identified chronologically early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators of clonal transmissibility. Thus, we provide the first insights into the specific genomic aberrations that underlie CTVT's dogged perseverance in canids around the world. |*Genetic Association Studies [MESH] |Animals [MESH] |Apoptosis [MESH] |Autoantigens/genetics [MESH] |CARD Signaling Adaptor Proteins/genetics [MESH] |Cell Adhesion Molecules/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Lineage/genetics [MESH] |Collagen Type XI/genetics [MESH] |DNA-Binding Proteins/genetics [MESH] |Dog Diseases/diagnosis/*genetics [MESH] |Dogs/*genetics [MESH] |Genetic Variation [MESH] |Genome [MESH] |Guanine Nucleotide Exchange Factors/genetics [MESH] |Heparan Sulfate Proteoglycans/genetics [MESH] |Microfilament Proteins/genetics [MESH] |Mutation [MESH] |Myotonin-Protein Kinase/genetics [MESH] |Phylogeny [MESH] |Principal Component Analysis [MESH] |Sequence Analysis, DNA [MESH]Comparison against 186 canid whole-genome sequences reveals survival s(epmc).pdf DeepDyve Pubget Overpricing