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10.1126/science.aab3632 http://scihub22266oqcxt.onion/10.1126/science.aab3632 C4617605!4617605!26229117     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26229117&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 349 (6253): 1228-32 Nephropedia Template TP {{tp|p=26229117|t=2015. Viruses transfer the antiviral second messenger cGAMP between cells |pdf=|usr=}}{{26229117}} gab.com Text Viruses transfer the antiviral second messenger cGAMP between cells JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26229117 #FOAvip Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP to newly infected cells and triggered a STING-dependent antiviral program. These effects were independent of exosomes and viral nucleic acids. Our results reveal a way by which a signal for innate immunity is transferred between cells, potentially accelerating and broadening antiviral responses. Moreover, infection of dendritic cells with cGAMP-loaded lentiviruses enhanced their activation. Loading viral vectors with cGAMP therefore holds promise for vaccine development. Twit Text FOAVip Viruses transfer the antiviral second messenger cGAMP between cells ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26229117 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26229117 #FOAvip English Wikipedia <ref>{{Cite pmid|26229117}}</ref> Viruses transfer the antiviral second messenger cGAMP between cells #MMPMID26229117 Bridgeman A; Maelfait J; Davenne T; Partridge T; Peng Y; Mayer A; Dong T; Kaever V; Borrow P; Rehwinkel J Science 2015[Sep]; 349 (6253): 1228-32 PMID26229117show ga Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP to newly infected cells and triggered a STING-dependent antiviral program. These effects were independent of exosomes and viral nucleic acids. Our results reveal a way by which a signal for innate immunity is transferred between cells, potentially accelerating and broadening antiviral responses. Moreover, infection of dendritic cells with cGAMP-loaded lentiviruses enhanced their activation. Loading viral vectors with cGAMP therefore holds promise for vaccine development. äViruses transfer the antiviral second messenger cGAMP between cells (epmc).pdf DeepDyve Pubget Overpricing