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10.1016/j.clim.2015.04.001 http://scihub22266oqcxt.onion/10.1016/j.clim.2015.04.001 C4617367!4617367 !25869297     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25869297 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Immunol 2015 ; 158 (2 ): 183-92 Nephropedia Template TP {{tp|p=25869297 |t=2015. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion |pdf=|usr=}}{{25869297 }} gab.com Text The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25869297 #FOAvip Little is known about the regulation of arthritis severity and joint damage in rheumatoid arthritis (RA). Fibroblast-like synoviocytes (FLS) have a central role in joint damage and express increased levels of the cation channel Trpv2. We aimed at determining the role of Trpv2 in arthritis. Treatment with Trpv2-specific agonists decreased the in vitro invasiveness of FLS from RA patients and arthritic rats and mice. Trpv2 stimulation suppressed IL-1?-induced expression of MMP-2 and MMP-3. Trpv2 agonists, including the new and more potent LER13, significantly reduced disease severity in KRN serum- and collagen-induced arthritis, and reduced histologic joint damage, synovial inflammation, and synovial blood vessel numbers suggesting anti-angiogenic activity. In this first in vivo use of Trpv2 agonists we discovered a new central role for Trpv2 in arthritis. These new compounds have the potential to become new therapies for RA and other diseases associated with inflammation, invasion, and angiogenesis. Twit Text FOAVip The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25869297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25869297 #FOAvip English Wikipedia <ref>{{Cite pmid|25869297 }}</ref> The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion #MMPMID25869297 Laragione T ; Cheng KF ; Tanner MR ; He M ; Beeton C ; Al-Abed Y ; Gulko PS Clin Immunol 2015[Jun]; 158 (2 ): 183-92 PMID25869297 show ga Little is known about the regulation of arthritis severity and joint damage in rheumatoid arthritis (RA). Fibroblast-like synoviocytes (FLS) have a central role in joint damage and express increased levels of the cation channel Trpv2. We aimed at determining the role of Trpv2 in arthritis. Treatment with Trpv2-specific agonists decreased the in vitro invasiveness of FLS from RA patients and arthritic rats and mice. Trpv2 stimulation suppressed IL-1?-induced expression of MMP-2 and MMP-3. Trpv2 agonists, including the new and more potent LER13, significantly reduced disease severity in KRN serum- and collagen-induced arthritis, and reduced histologic joint damage, synovial inflammation, and synovial blood vessel numbers suggesting anti-angiogenic activity. In this first in vivo use of Trpv2 agonists we discovered a new central role for Trpv2 in arthritis. These new compounds have the potential to become new therapies for RA and other diseases associated with inflammation, invasion, and angiogenesis. |Animals [MESH] |Arthritis, Rheumatoid/metabolism/pathology [MESH] |Arthritis/*chemically induced [MESH] |Calcium Channels/genetics/*metabolism [MESH] |Cannabidiol/analogs & derivatives/pharmacology [MESH] |Cannabinoids/pharmacology [MESH] |Collagen/toxicity [MESH] |Fibroblasts/*physiology [MESH] |Humans [MESH] |Mice [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH] |Rats [MESH] |Synovial Membrane/*cytology/drug effects [MESH] |TRPV Cation Channels/agonists/genetics/*metabolism [MESH] |Terpenes/toxicity [MESH]The cation channel Trpv2 is a new suppressor of arthritis severity, jo(epmc).pdf DeepDyve Pubget Overpricing