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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Lipid+Res
2014 ; 55
(11
): 2401-7
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gab.com Text
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Short-term n-3 fatty acid supplementation but not aspirin increases plasma
proresolving mediators of inflammation
#MMPMID25187667
Barden A
; Mas E
; Croft KD
; Phillips M
; Mori TA
J Lipid Res
2014[Nov]; 55
(11
): 2401-7
PMID25187667
show ga
Resolution of inflammation is an active process involving specialized
proresolving mediators (SPM) formed from the n-3 fatty acids. This study examined
the effect of n-3 fatty acid supplementation and aspirin on plasma SPMs in
healthy humans. Healthy volunteers (n = 21) were supplemented with n-3 fatty
acids (2.4g/day) for 7 days with random assignment to take aspirin (300 mg/day)
or placebo from day 5 to day 7. Blood was collected at baseline (day 0), day 5,
and day 7. Plasma 18R/S-HEPE, E-series resolvins, 17R/S-HDHA, D-series resolvins,
14R/S-HDHA, and MaR-1 were measured by LC/MS/MS. At baseline concentrations of E-
and D- series resolvins and the upstream precursors 18R/S-HEPE, 17R/S-HDHA ranged
from 0.1nM to 0.2nM. 14R/S-HDHA was 3-fold higher than the other SPMs at baseline
but MaR-1 was below the limit of detection. Supplementation with n-3 fatty acids
significantly increased RvE1, 18R/S-HEPE, 17R/S-HDHA, and 14R/S-HDHA but not
other SPMs. The addition of aspirin after 5 days of n-3 fatty acids did not
affect concentrations of any SPM. N-3 fatty acid supplementation for 5 days
results in concentrations of SPMs that are biologically active in healthy humans.
Aspirin administered after n-3 fatty acids did not offer any additional benefit
in elevating the levels of SPMs.