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10.1194/jlr.M051839 http://scihub22266oqcxt.onion/10.1194/jlr.M051839 C4617137!4617137 !25267995     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25267995 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2014 ; 55 (11 ): 2354-69 Nephropedia Template TP {{tp|p=25267995 |t=2014. Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction |pdf=|usr=}}{{25267995 }} gab.com Text Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=25267995 #FOAvip Mammalian kidneys are rich in sulfatides. Papillary sulfatides, especially, contribute to renal adaptation to chronic metabolic acidosis. Due to differences in their cer-amide (Cer) anchors, the structural diversity of renal sulfatides is large. However, the underling biological function of this complexity is not understood. As a compound's function and its tissue location are intimately connected, we analyzed individual renal sulfatide distributions of control and Cer synthase 2 (CerS)2-deficient mice by imaging MS (IMS) and by LC-MS(2) (in controls for the cortex, medulla, and papillae separately). To explain locally different structures, we compared our lipid data with regional mRNA levels of corresponding anabolic enzymes. The combination of IMS and in source decay-LC-MS(2) analyses revealed exclusive expression of C20-sphingosine-containing sulfatides within the renal papillae, whereas conventional C18-sphingosine-containing compounds were predominant in the medulla, and sulfatides with a C18-phytosphingosine were restricted to special cortical structures. CerS2 deletion resulted in bulk loss of sulfatides with C23/C24-acyl chains, but did not lead to decreased urinary pH, as previously observed in sulfatide-depleted kidneys. The reasons may be the almost unchanged C22-sulfatide levels and constant total renal sulfatide levels due to compensation with C16- to C20-acyl chain-containing compounds. Intriguingly, CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensation. Twit Text FOAVip Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=25267995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25267995 #FOAvip English Wikipedia <ref>{{Cite pmid|25267995 }}</ref> Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction #MMPMID25267995 Marsching C ; Rabionet M ; Mathow D ; Jennemann R ; Kremser C ; Porubsky S ; Bolenz C ; Willecke K ; Gröne HJ ; Hopf C ; Sandhoff R J Lipid Res 2014[Nov]; 55 (11 ): 2354-69 PMID25267995 show ga Mammalian kidneys are rich in sulfatides. Papillary sulfatides, especially, contribute to renal adaptation to chronic metabolic acidosis. Due to differences in their cer-amide (Cer) anchors, the structural diversity of renal sulfatides is large. However, the underling biological function of this complexity is not understood. As a compound's function and its tissue location are intimately connected, we analyzed individual renal sulfatide distributions of control and Cer synthase 2 (CerS)2-deficient mice by imaging MS (IMS) and by LC-MS(2) (in controls for the cortex, medulla, and papillae separately). To explain locally different structures, we compared our lipid data with regional mRNA levels of corresponding anabolic enzymes. The combination of IMS and in source decay-LC-MS(2) analyses revealed exclusive expression of C20-sphingosine-containing sulfatides within the renal papillae, whereas conventional C18-sphingosine-containing compounds were predominant in the medulla, and sulfatides with a C18-phytosphingosine were restricted to special cortical structures. CerS2 deletion resulted in bulk loss of sulfatides with C23/C24-acyl chains, but did not lead to decreased urinary pH, as previously observed in sulfatide-depleted kidneys. The reasons may be the almost unchanged C22-sulfatide levels and constant total renal sulfatide levels due to compensation with C16- to C20-acyl chain-containing compounds. Intriguingly, CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensation. |Animals [MESH] |Female [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Kidney/*metabolism [MESH] |Mice [MESH] |Molecular Imaging [MESH] |Organ Specificity [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Serine C-Palmitoyltransferase/genetics [MESH] |Sphingosine N-Acyltransferase/deficiency/genetics/*metabolism [MESH]Renal sulfatides: sphingoid base-dependent localization and region-spe(epmc).pdf DeepDyve Pubget Overpricing