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2015 ; 4
(ä): 179
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Expression of ZFX gene correlated with the central features of the neoplastic
phenotype in human brain tumors with distinct phenotypes
#MMPMID26605218
Afzali A
; Emadi-Baygi M
; Nikpour P
; Nazemroaya F
; Kheirollahi M
Adv Biomed Res
2015[]; 4
(ä): 179
PMID26605218
show ga
BACKGROUND: The zinc finger transcription factor zinc finger protein, X-linked
(ZFX) acts as an important director of self-renewal in several stem cell types.
Moreover, ZFX expression abnormally increases in various cancers and relates to
tumor grade. We performed this study, to examine its role in the pathogenesis of
astrocytoma and meningioma. MATERIALS AND METHODS: We used real-time reverse
transcription polymerase chain reaction method for evaluation of ZFX expression
in 25 astrocytoma tumoral tissue and 25 meningioma tumoral tissues with different
WHO grades. Furthermore, the association of gene expression with various
clinic-pathological characteristics was examined. RESULTS: We found that there is
a significant association between gene expression and different tumor grades, the
presence or absence of invasion, forming and nonforming of glomeruloid vessels,
the age over or under 50 and the presence or absence of calcification in
astrocytomas. This is the first report that shows that ZFX was directly
correlated with the central features of the neoplastic phenotype, including the
growth of cancer cells, angiogenesis, and invasion. CONCLUSION: Regarding all the
above-mentioned studies, it is highly plausible that silencing the expression of
ZFX gene in gliomas has a major role in the therapeutic interventions of the
disease in future.