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10.15171/apb.2015.044 http://scihub22266oqcxt.onion/10.15171/apb.2015.044 C4616885!4616885!26504752     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Pharm+Bull 2015 ; 5 (3): 315-20 Nephropedia Template TP {{tp|p=26504752|t=2015. Ghrelin Decreases Angiogenesis, HIF-1? and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats |pdf=|usr=}}{{26504752}} gab.com Text Ghrelin Decreases Angiogenesis, HIF-1 and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats JO: Adv Pharm Bull http://www.kidney.de/pget.php?&tw=1&pmid=26504752 #FOAvip Purpose: Hypoxia is a condition of decreased availability of oxygen. When cells are exposed to a low oxygen environment, they impel the hypoxia responses to adapt to new situation. The hypoxia response leads to the activation of various cellular signaling pathways. The aim of this study was to evaluate the effect of ghrelin on angiogenesis, Hypoxia-Inducible-Factor-1? (HIF-1) and Vascular endothelial growth factor (VEGF) levels in normobaric hypoxia situation.Methods: Twenty four animals were divided into 4 groups (n=6): control (C), ghrelin (Gh), hypoxia (H), and hypoxic animals that received ghrelin (H+Gh). Hypoxia (11%) was induced by an Environmental Chamber System GO2 Altitude. Animals in ghrelin groups received a subcutaneous injection of ghrelin (150 ?g/kg/day) for 14 days.Results: Our results showed that hypoxia significantly (p<0.05) increased angiogenesis without any significant changes on HIF-1 and VEGF levels, whereas ghrelin significantly (p<0.05) decreased angiogenesis, expression of HIF-1 and VEGF in this condition. Ghrelin administration did not show any significant changes in normal conditions.Conclusion: Ghrelin had no effect on angiogenesis, expression of HIF-1 and VEGF in normal oxygen conditions but it reduced angiogenesis process in lung tissue with reducing the level of HIF and VEGF in hypoxic condition. Therefore, effect of ghrelin on angiogenesis could be related to blood oxygen level. Twit Text FOAVip Ghrelin Decreases Angiogenesis, HIF-1 and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats ????Adv Pharm Bull http://www.kidney.de/pget.php?&tw=1&pmid=26504752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26504752 #FOAvip English Wikipedia <ref>{{Cite pmid|26504752}}</ref> Ghrelin Decreases Angiogenesis, HIF-1? and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats #MMPMID26504752 Mirzaei Bavil F; Alipour MR; Keyhanmanesh R; Alihemmati A; Ghiyasi R; Mohaddes G Adv Pharm Bull 2015[Sep]; 5 (3): 315-20 PMID26504752show ga Purpose: Hypoxia is a condition of decreased availability of oxygen. When cells are exposed to a low oxygen environment, they impel the hypoxia responses to adapt to new situation. The hypoxia response leads to the activation of various cellular signaling pathways. The aim of this study was to evaluate the effect of ghrelin on angiogenesis, Hypoxia-Inducible-Factor-1? (HIF-1) and Vascular endothelial growth factor (VEGF) levels in normobaric hypoxia situation.Methods: Twenty four animals were divided into 4 groups (n=6): control (C), ghrelin (Gh), hypoxia (H), and hypoxic animals that received ghrelin (H+Gh). Hypoxia (11%) was induced by an Environmental Chamber System GO2 Altitude. Animals in ghrelin groups received a subcutaneous injection of ghrelin (150 ?g/kg/day) for 14 days.Results: Our results showed that hypoxia significantly (p<0.05) increased angiogenesis without any significant changes on HIF-1 and VEGF levels, whereas ghrelin significantly (p<0.05) decreased angiogenesis, expression of HIF-1 and VEGF in this condition. Ghrelin administration did not show any significant changes in normal conditions.Conclusion: Ghrelin had no effect on angiogenesis, expression of HIF-1 and VEGF in normal oxygen conditions but it reduced angiogenesis process in lung tissue with reducing the level of HIF and VEGF in hypoxic condition. Therefore, effect of ghrelin on angiogenesis could be related to blood oxygen level. äGhrelin Decreases Angiogenesis, HIF-1? and VEGF Protein Levels in Chro(epmc).pdf DeepDyve Pubget Overpricing