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2015 ; 94
(39
): e1390
Nephropedia Template TP
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Citrus Fruit Intake Substantially Reduces the Risk of Esophageal Cancer: A
Meta-Analysis of Epidemiologic Studies
#MMPMID26426606
Wang A
; Zhu C
; Fu L
; Wan X
; Yang X
; Zhang H
; Miao R
; He L
; Sang X
; Zhao H
Medicine (Baltimore)
2015[Sep]; 94
(39
): e1390
PMID26426606
show ga
Many epidemiologic studies indicate a potential association between fruit and
vegetable intake and various cancers. The purpose of this meta-analysis is to
investigate the association between citrus fruit intake and esophageal cancer
risk. The authors conducted a comprehensive search on PubMed, EMBASE, and the
Cochrane Library from inception until July 2014. Studies presenting information
about citrus intake and esophageal cancer were analyzed. The authors extracted
the categories of citrus intake, study-specific odds ratio or relative risk, and
the P value and associated 95% confidence intervals for the highest versus lowest
dietary intake of citrus fruit level. The association was quantified using
meta-analysis of standard errors with a random-effects model. Thirteen
case-control studies and 6 cohort studies were eligible for inclusion. Citrus
intake may significantly reduce risk of esophageal cancer (summary odds ratio =
0.63; 95% confidence interval = 0.52-0.75; P = 0), without notable publication
bias (intercept = -0.79, P = 0.288) and with significant heterogeneity across
studies (I = 52%). The results from epidemiologic studies suggest an inverse
association between citrus fruit intake and esophageal cancer risk. The
significant effect is consistent between case-control and cohort studies. Larger
prospective studies with rigorous methodology should be considered to validate
the association between citrus fruits and esophageal cancer.