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2015 ; 94
(39
): e1590
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gab.com Text
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Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A
Prospective, Longitudinal Study With Protocol Biopsies
#MMPMID26426636
Lee J
; Oh YT
; Joo DJ
; Ma BG
; Lee AL
; Lee JG
; Song SH
; Kim SU
; Jung DC
; Chung YE
; Kim YS
Medicine (Baltimore)
2015[Sep]; 94
(39
): e1590
PMID26426636
show ga
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney
allograft loss. Several noninvasive techniques developed to assess tissue
fibrosis are widely used to examine the liver. However, relatively few studies
have investigated the use of elastographic methods to assess transplanted
kidneys. The aim of this study was to explore the clinical implications of the
acoustic radiation force impulse (ARFI) technique in renal transplant patients. A
total of 91 patients who underwent living donor renal transplantation between
September 2010 and January 2013 were included in this prospective study. Shear
wave velocity (SWV) was measured by ARFI at baseline and predetermined time
points (1 week and 6 and 12 months after transplantation). Protocol biopsies were
performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be
related to time elapsed after transplantation. Mean SWV increased continuously
during the first postoperative year (P < 0.001). In addition, mixed model
analysis showed no correlation existed between SWV and serum creatinine (r =
-0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA
and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV
temporal patterns were dependent on the kidney weight to body weight ratio
(KW/BW). In patients with a KW/BW < 3.5 g/kg, mean SWV continuously increased for
12 months, whereas it decreased after 6 months in those with a KW/BW ? 3.5
g/kg.No significant correlation was observed between SWV and IF/TA or renal
dysfunction. However, SWV was found to be related to the time after
transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.