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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(41
): e1617
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Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced
Cardiovascular Damage and Renal Alterations
#MMPMID26469898
Blázquez-Medela AM
; García-Sánchez O
; Quirós Y
; Blanco-Gozalo V
; Prieto-García L
; Sancho-Martínez SM
; Romero M
; Duarte JM
; López-Hernández FJ
; López-Novoa JM
; Martínez-Salgado C
Medicine (Baltimore)
2015[Oct]; 94
(41
): e1617
PMID26469898
show ga
Early detection of hypertensive end-organ damage and secondary diseases are key
determinants of cardiovascular prognosis in patients suffering from arterial
hypertension. Presently, there are no biomarkers for the detection of
hypertensive target organ damage, most outstandingly including blood vessels, the
heart, and the kidneys.We aimed to validate the usefulness of the urinary
excretion of the serine protease kallikrein-related peptidase 9 (KLK9) as a
biomarker of hypertension-induced target organ damage.Urinary, plasma, and renal
tissue levels of KLK9 were measured by the Western blot in different rat models
of hypertension, including angiotensin-II infusion, DOCA-salt, L-NAME
administration, and spontaneous hypertension. Urinary levels were associated to
cardiovascular and renal injury, assessed by histopathology. The origin of
urinary KLK9 was investigated through in situ renal perfusion experiments.The
urinary excretion of KLK9 is increased in different experimental models of
hypertension in rats. The ACE inhibitor trandolapril significantly reduced
arterial pressure and the urinary level of KLK9. Hypertension did not increase
kidney, heart, liver, lung, or plasma KLK9 levels. Hypertension-induced increased
urinary excretion of KLK9 results from specific alterations in its tubular
reabsorption, even in the absence of overt nephropathy. KLK9 urinary excretion
strongly correlates with cardiac hypertrophy and aortic wall thickening.KLK9
appears in the urine in the presence of hypertension as a result of subtle renal
handling alterations. Urinary KLK9 might be potentially used as an indicator of
hypertensive cardiac and vascular damage.
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