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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(41
): e1772
Nephropedia Template TP
gab.com Text
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English Wikipedia
Hong Kong Liver Cancer Staging System Is Associated With Better Performance for
Hepatocellular Carcinoma: Special Emphasis on Viral Etiology
#MMPMID26469917
Liu PH
; Hsu CY
; Lee YH
; Su CW
; Hsia CY
; Huang YH
; Chiou YY
; Lin HC
; Huo TI
Medicine (Baltimore)
2015[Oct]; 94
(41
): e1772
PMID26469917
show ga
Hong Kong Liver Cancer (HKLC) staging system was developed for prognostic and
treatment evaluation for hepatocellular carcinoma (HCC) but is not externally
validated. We aimed to evaluate and compare HKLC system with Barcelona Clínic
Liver Cancer (BCLC) staging system. The prognostic performance, discriminatory
ability, and efficacy of treatment recommendations were compared between the BCLC
and HKLC systems. Significant differences in survival were found across all
stages of BCLC and across stages I to IV of HKLC systems (P?0.01). HKLC system
was associated with higher homogeneity in prognostic accuracy. The survival was
similar between patients treated according to the HKLC or BCLC system (P?=?0.07).
However, more patients were treated according to HKLC recommendations than to
BCLC recommendations (57% vs. 47%, P?0.001). In a hypothetical cohort created
by random sampling, patients treated according to the HKLC scheme had better
survival compared with patients treated according to the BCLC system
(P?0.001).Subgroup analyses between hepatitis B virus (HBV) and hepatitis C
virus (HCV)-related HCC were performed. More HCV-related HCC were at earlier BCLC
or HKLC stages (both P?0.001). The HKLC system was more informative with
greater homogeneity in predicting survival in both HBV and HCV cohorts. However,
HKLC treatment recommendations were associated with better long-term survival
only in HBV-related HCC but not in HCV-related HCC (P?0.001 and P?=?0.79,
respectively).In conclusion, we provided external validation of the HKLC system.
Compared with the BCLC system, the HKLC system has better prognostic accuracy and
therapeutic efficacy in the entire cohort and in HBV-related HCC but not in
HCV-related HCC. Due to high heterogeneity among patients of various etiologies,
staging and treatment strategies tailored to specific HCC etiology are required.