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2015 ; 94
(41
): e1576
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Is the Preoperative Administration of Amiodarone or Metoprolol More Effective in
Reducing Atrial Fibrillation: After Coronary Bypass Surgery?
#MMPMID26469896
Onk OA
; Erkut B
Medicine (Baltimore)
2015[Oct]; 94
(41
): e1576
PMID26469896
show ga
This study examined the influence of preoperative administration of amiodarone
and metoprolol in preventing postoperative atrial fibrillation (AF) after
coronary artery bypass grafting (CABG) surgery.The study comprised 251 patients
who underwent CABG surgery at our hospital between January 2012 and May 2014. The
patients were randomly divided into 2 groups: amiodarone therapy group (n?=?122
patients) and metoprolol therapy group (n?=?129 patients).In the amiodarone
group, the patients received amiodarone tablet orally 1 week before coronary
bypass surgery and during the postoperative period. In the metoprolol group, the
patients received metoprolol tablet orally 1 week before surgery and during the
postoperative period. The AF development rate was retrospectively evaluated
between the first 3 days and 4 weeks after surgery.AF developed in 14 patients in
the amiodarone group and 16 patients in the metoprolol group 4 weeks after the
operation (P?=?0.612).No significant difference was observed between the groups
in terms of intensive care unit and hospital stay. Furthermore, hospital charges
were similar in both groups (P?=?0.741).The results of the logistic regression
analysis showed age, left ventricular ejection fraction, left atrial diameter,
and aortic cross-clamping time to be predictors for postoperative AF.This study
demonstrates that amiodarone and metoprolol have similar effects in prevention of
AF after cardiac surgery. However, larger-scale studies need to be conducted to
substantiate these findings.