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2015 ; 94
(32
): e1338
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Pars Plana Vitrectomy and Evisceration Resulting in Death Due to Misdiagnosis of
Retinoblastoma in Children: A Review of 3 Cases
#MMPMID26266382
Shen T
; Liu R
; Lin J
; Huang H
; Li X
; Yan J
Medicine (Baltimore)
2015[Aug]; 94
(32
): e1338
PMID26266382
show ga
Retinoblastoma is a curable intraocular malignancy in children. However, in
clinical practice, retinoblastoma can sometimes be misdiagnosed and mismanaged,
leading to extraocular extension and even death. In this report, a series of 3
cases are related that emphasize the conditions and consequences resulting from
misdiagnosis and mismanagement of retinoblastoma. The clinical features, imaging
findings, histopatholigical examination, and management in 3 case reports of
children with misdiagnosed retinoblastoma are presented. Two of the cases
received pars plana vitrectomy after being misdiagnosed with Coats disease or
ocular blunt trauma, whereas the third case received evisceration after being
misdiagnosed with suppurative endophthalmitis. When the diagnosis of
retinoblastoma had been confirmed after a second surgery was performed in our
hospital, only 2 of the cases received adjuvant orbital radiotherapy. All 3 cases
died of systemic tumor metastases. Intraocular surgical procedures should be
avoided in any equivocal case until the possibility of latent retinoblastoma is
eliminated.We strongly recommend that early enucleation be executed as soon as
possible followed by postoperative adjuvant therapy under conditions wherein an
intraocular surgery was inadvertently performed in an eye with retinoblastoma.