The Clinicopathologic and Prognostic Significance of Gross Classification on
Solitary Hepatocellular Carcinoma After Hepatectomy
#MMPMID26266378
He J
; Shi J
; Fu X
; Mao L
; Zhou T
; Qiu Y
; Zhu B
Medicine (Baltimore)
2015[Aug]; 94
(32
): e1331
PMID26266378
show ga
The prevalence of hepatitis B virus (HBV) infection is extremely high in China.
We aimed to investigate the clinicopathologic and prognostic significance of
gross classification on solitary hepatocellular carcinoma (HCC) after
hepatectomy.A total of 144 patients with solitary HCC who underwent hepatectomy
were identified retrospectively. Based on the gross appearance, the tumors were
divided into single nodular (SN), single nodular with extranodular growth (SNEG),
confluent multinodular (CMN), and infiltrative types. Clinicopathologic variables
and survival information were compared among patients with those 4 types.The 144
tumors composed of 25 SN, 34 SNEG, 33 CMN, and 52 infiltrative types. The serum
alpha-fetoprotein (AFP) level and HBV infection rate of infiltrative type were
significantly higher than other 3 types. The disease-free and overall survival
times of infiltrative type were significantly shorter than other 3 types.
Univariate and multivariate analysis showed that gross classification,
microvascular invasion, and T stage were independent risk factors.In Chinese
patients with solitary HCC, the infiltrative type accounted for a much higher
proportion compared with other regions of the world. Infiltrative HCC had higher
serum AFP level, HBV infection, and microvascular invasion rates with poorer
prognosis compared with other 3 types.
free
free
free
